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US 2023/0348365 A1Published application
Compounds for treating infections
AssigneeHoritzonts Tecnologics Hungary KorláTolt FelelosséGu TáRsasáG
InventorsAlfredo HERNÁNDEZ CABANILLAS, Santiago MADERUELO CORRAL, Montserrat ORTEGA DOMÉNECH, Diego Fernando ROSERO VALENCIA, Ángel RUMBERO SÁNCHEZ, Victor TENA PÉREZ
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Abstract
The invention relates to hydrazide compounds and their use in medicine, particularly in treating and/or preventing infections caused by a fungus.
Claims19
1-10. (canceled)
A method for the prevention and/or treatment of an infection caused by a fungus, bacterium or virus in a subject in need thereof which comprises the administration of a pharmaceutical composition comprising a compound of formula (II)
- or a pharmaceutically acceptable salt, stereoisomer or solvate thereof,
- wherein
- Y1═O;
- Y2═O;
- W═NH
- n=0, 1;
- R2═NHR4, and wherein R4 is selected from OH, —NH2, —NH—CH3 and —NRaRb, wherein Ra and Rb are independently selected from C1-6 alkyl groups or aryl groups,
- Q is selected from a group consisting of:
- a) 1-pyridine, 2-pyridine, 3-pyridine,
- b) phenyl optionally substituted with one or more groups independently selected from C1-8 alkyl, C2-8 alkenyl, halogen, —SH, —OR5, —SR5, —OH, —NO2, —C(O)NH—R5, —C(O)OR5, —OC(O)R5, —CF3, —CN, —NH2, —NHOH, —NH—NH2, —NH—CH3 and —NR6R7, wherein R5 is C1-6 alkyl, aryl, or hydrogen, wherein R6 and R7 are independently selected from C1-6 alkyl groups, aryl groups, —C(O)R5, —OC(O) R5, or —C(O) OR5—,
- c) 5-6 membered aromatic ring having one or more heteroatoms selected from N, S, and O and being optionally substituted with one or more groups independently selected from:
- C1-8 alkyl, linear or branched C1-8 alkenyl, C5-6 cycloalkyl,
- phenyl as defined in b),
- 5-6 membered aromatic ring group having one or more heteroatoms selected from N, S, and O,
- halogen,
- (C1-6alkyl)OCH2—,
- C1-6 alkoxy,
- NRaRb, wherein Ra and Rb are independently selected from C1-6 alkyl groups or aryl groups, and
- NHC(O)R5—, —C(O)NH—R5, —OC(O)R5, and —C(O)OR5—, wherein R5 is C1-6 alkyl, aryl or hydrogen, and
- d) a fused bicyclic ring containing at least one phenyl group and a C5-6 aromatic heterocyclic group having one or more heteroatoms selected from N, S, and O, wherein the phenyl group of said fused bicyclic ring is optionally substituted with one or more groups independently selected from
- C1-8 alkyl, linear or branched C1-8 alkenyl, C5-6 cycloalkyl,
- phenyl as defined in b),
- 5-6 membered aromatic ring group as defined in c),
- halogen,
- (C1-6alkyl)OCH2—,
- C1-6 alkoxy,
- OH, —SH or —SR5 wherein R5 is C1-6 alkyl, aryl or hydrogen,
- NR6R7, wherein R6 and R7 are independently selected from C1-6 alkyl groups, aryl groups, C(O)R5, —OC(O)R5, or —C(O)OR5, wherein R5 is C1-6 alkyl, aryl or hydrogen, and
- NHC(O) R5—, —C(O)NH—R5, —OC(O) R5, or —C(O) OR5—, wherein R5 is C1-6 alkyl, aryl, or hydrogen,
- and a pharmaceutically acceptable excipient to a subject in need thereof.
27 more elements
Dependencies are inferred from the claim text.