Methods and agents for the detection and treatment of cancer
OwnerJames BASILION, Andrew JOHNSON +2inventors
InventorsJames BASILION, Andrew JOHNSON, Dong LUO, Thomas MEADE
Life of this patent
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Abstract
A nanoparticle agent includes a gold nanoparticle, at least one thiol modified Gd(III) macrocycle complex, and at least one prostate specific membrane antigen (PSMA) ligand, wherein the PSMA ligand and the thiol modified Gd(III) complex are each individually coupled to the gold nanoparticle via one or more thiol (SH) groups.
Claims37
A nanoparticle agent for use in detecting, monitoring, and/or imaging cancer cells and/or cancer cell metastasis, migration, dispersal, and/or invasion, and/or for treating cancer in a subject, the nanoparticle agent comprising:
- a gold nanoparticle;
- at least one thiol modified Gd(III) macrocycle complex coupled to the gold nanoparticle;
- and
- at least one prostate specific membrane antigen (PSMA) ligand coupled to the gold nanoparticle for targeting the composition to a PSMA expressing cancer cell,
- wherein the PSMA ligand and the Gd(III) complex are each individually directly coupled to the gold nanoparticle via one or more thiol (SH) groups.
A method of detecting, monitoring, and/or imaging cancer cells and/or cancer cell metastasis, migration, dispersal, and/or invasion, in a subject, the agent comprising:
- (a) administering to a subject with cancer a diagnostically effective amount of a nanoparticle agent, the nanoparticle agent comprising:
- a gold nanoparticle;
- at least one thiol modified Gd(III) macrocycle complex coupled to the gold nanoparticle;
- and
- at least one prostate specific membrane antigen (PSMA) ligand coupled to the gold nanoparticle for targeting the nanoparticle agent to a PSMA expressing cancer cell, wherein the PSMA ligand and the Gd(III) complex are each individually coupled to the gold nanoparticle via one or more thiol (SH) groups;
- and
- (b) detecting the nanoparticle agent selectively targeted to the cancer cells to determine the location and/or distribution of the cancer cells in the subject.
A method for treating cancer in a subject in need thereof comprising:
- (a) administering to a subject with cancer a therapeutically effective amount of a nanoparticle agent, the nanoparticle agent comprising:
- a gold nanoparticle;
- at least one thiol modified Gd(III) macrocycle complex;
- and
- at least one prostate specific membrane antigen (PSMA) ligand coupled to the gold nanoparticle for targeting the nanoparticle agent to a PSMA expressing cancer cells in the subject,
- wherein the PSMA ligand and the Gd(III) complex are each individually coupled to the gold nanoparticle via one or more thiol (SH) groups;
- (b) detecting nanoparticle agents selectively targeted to the cancer cells to determine the location and/or distribution of the cancer cells in the subject;
- and
- (c) irradiating the cancer cells, thereby inducing the radiosensitizing effects of the nanoparticle agents.
Dependencies are inferred from the claim text.