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US 2023/0346971 A1Published application
Method for treating tumours by capturing copper and/or iron
AssigneesLyon Ingenierie Projects, Universite Claude Bernard Lyon 1, Mexbrain, Centre National De La Recherche Scentifique (Cnrs), INSERM (Institut National de la Santé de la Médicale), Hospice Civils De Lyon, Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnemt
InventorsOlivier TILLEMENT, François LUX, Delphine VERNOS, Claire RODRIGUEZ-LAFRASSE, Thomas BRICHART, Marco NATUZZI, Alain GELOEN, Simon CHAMPAGNE, Matteo MARTINI, Paul ROCCHI
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Abstract
The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.
Claims20
A nanoparticle of the following formula:
- [Ch1]n—PS—[Ch2]m,
- wherein:
- PS is an organic or inorganic polymer matrix,
- Ch1 is a chelating group which is uncomplexed or is complexed with a metal cation M1,
- M1 is absent, or selected from metal cations for which the constant for complex formation with Ch1 is less than that of copper,
- Ch2 is a chelating group, identical to or different from the chelating group Ch1, and complexed with a metal cation M2 having a high atomic number Z, greater than 40
- wherein,
- (i) the chelating agents Ch1 and Ch2 are grafted to the polymer matrix,
- (ii) the n/(n+m) ratio is between 10% and 100%, and
- (iii) the mean hydrodynamic diameter of the nanoparticle is between 1 and 50 nm.
7 more elements
Dependencies are inferred from the claim text.