System and method for single-scan rest-stress cardiac pet

A system for performing a single-scan rest-stress cardiac measurement, the system comprising:

• a positron emission tomography (PET) imaging system;
• a source of a first PET radiotracer for administration to a subject;
• a source of a second PET radiotracer for administration to a subject;
• and
• a processor having non-transient computer readable media programmed with instructions to cause the processor to obtain PET listmode data from the subject administered with the radiotracer, the instructions further causing the processor to process the PET listmode data by way of a direct parametric reconstruction (DPR) of kinetic parameters from the listmode data,
• wherein an output of the DPR is a measure of myocardial blood flow for both a rest state and a stress state of the subject.

A system for estimating kinetic parameters of blood flow of a subject, the system comprising:

• a processor having non-transient computer readable media programmed with instructions to cause the processor to:
• obtain PET image data from the subject, the PET image data acquired and timed with at least one real-time measurement of a physiological variance of the subject;
• access a model for estimating kinetic parameters within of a kinetic region of interest in the PET image data from the non-transient computer readable media, the kinetic parameters based on an expression of the radiotracer within the PET image data,
• generate a report of at least one kinetic parameter of blood flow based on the kinetic parameters estimated from the PET image data.