Mutant orf viruses and uses thereof
AssigneeSuzhou Prajna Biotech Co., Ltd.
InventorMinjie HU
Life of this patent
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Abstract
Provided are the use of a mutant Ovis spp. infectious pustular dermatitis virus (ORFV) and a pharmaceutical composition thereof in the treatment of cancer.
Claims21
A mutant orf virus, wherein the functionally expressed product of the ORFV112 gene and/or the ORFV111 gene is absent.
A mutant orf virus, characterized by complete or partial deletion of the ORFV112 gene, and/or complete or partial deletion of the ORFV111 gene.
A method for modifying an orf virus comprising reducing or suppressing the expression and/or activity of the ORFV112 gene product, and/or reducing or suppressing the expression and/or activity of the ORFV111 gene product.
A method for modifying an orf virus comprising deleting the ORFV112 gene completely or partially, and/or deleting the ORFV111 gene completely or partially.
An orf virus deposited at China Center for Type Culture Collection (CCTCC) with the accession number V20202.
Dependencies are inferred from the claim text.