Preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates

Abstract

The present disclosure provides preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates. The nitrification intermediate has a structure shown in Formula I. Formula I is R2 is a hydroxyl, and R3 is H; or, R2 is H, and R3 is a hydroxyl; and R1 and R4 are independently selected from C1˜C12 electron donor groups. The preparation method includes the following steps: performing monohydroxy protection on a compound A with a hydroxy protection reagent in the presence of an acid binding agent to form a monohydroxy protection compound, herein R1, R2, R3 and R4 in the compound A have the same definition as above, and the hydroxy protection reagent is p-toluenesulfonyl chloride and 1-hydroxybenzotriazole; and performing a nitrification reaction and a deprotection reaction on the monohydroxy protection compound successively to obtain the nitrification intermediate.

Dependencies are inferred from the claim text.