Antagonistic peptide targeting il-2, il-9, and il-15 signaling for the treatment of cytokinerelease syndrome and cytokine storm associated disorders
AssigneeBioniz, LLC
InventorsYutaka Tagaya, Nazli Azimi
Life of this patent
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Abstract
The yc-family Interleukin-2 (IL-2), Interleukin-9 (IL-9), and Interleukin-15 (IL-15) cytokines are associated with important human diseases, such as cytokine-release syndrome and cytokine storm associated disorders. Compositions, methods, and kits to modulate signaling by at least one IL-2, IL-9, or IL-15 γc-cytokine family members for inhibiting, ameliorating, reducing a severity of, treating, delaying the onset of, or preventing at least one cytokine storm related disorder are described.
Claims47
A composition, comprising:
- an effective amount of a therapeutic compound, wherein the effective amount of the therapeutic compound is an amount sufficient to modulate signaling by at least one IL-2, IL-9, and IL-15 γc-cytokine family member and to thereby inhibit, ameliorate, reduce a severity of, treat, delay the onset of, or prevent at least one cytokine storm related disorder;
- and
- a pharmaceutically acceptable carrier.
A method of designing a γc-cytokine antagonist peptide and/or a derivative thereof configured to modulate and/or block signaling by at least one IL-2, IL-9, and IL-15 γc-cytokine family member that inhibits, ameliorates, reduces a severity of, treats, delays the onset of, or prevents at least one cytokine storm related disorder, the method comprising the steps of:
- using a computer to obtain from an amino acid sequence database amino acid sequences of at least one IL-2 and IL-15 γc-cytokine family member,
- assembling a γc-cytokine antagonist peptide and/or a derivative thereof based on a sequence of the at least one IL-2 and IL-15 γc-cytokine family member,
- wherein the γc-cytokine antagonist peptide and/or the derivative thereof modulates and/or blocks signaling by the at least one IL-2, IL-9, and IL-15 γc-cytokine family member.
Dependencies are inferred from the claim text.