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AssigneesAuburn University, Edward Via College of Osteopathic Medicine - Auburn
InventorsTatiana I. SAMOYLOVA, Alexandre M. SAMOYLOV, Kenny V. BROCK, Anna M. COCHRAN, James W. GILLESPIE
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Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.
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A homogenous population of recombinant bacteriophage comprising an exogenous amino acid sequence that binds to an anti-CD47 antibody.
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A method for selecting peptides that bind to an anti-CD47 antibody, the method comprising:
An immunogenic composition for inducing an immune response against cancer cells comprising a peptide-based antigen mimic and a peptide carrier wherein the peptide-based antigen mimic induces an immune response against CD47.
Dependencies are inferred from the claim text.