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US 2023/0331824 A1Published application
Single-domain antibodies that bind sars-cov-2
AssigneesThe Rockefeller University, Seattle Children's Hospital d/b/a Seattle Children's Research Institute, New York University
InventorsBrian T. Chait, Michael P. Rout, John Aitchison, Fred David Mast, Jean Paul Olivier, David Fenyo
Life of this patent
Estimating the term…
Abstract
Single-domain antibodies that bind the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) spike protein are disclosed. The single-domain antibodies include binding domains that bind epitopes of the Spike ectodomain inside and outside the receptor binding domain. The single-domain antibodies can be used for multiple purposes including in the research, diagnosis, and prophylactic or therapeutic treatment of COVID-19.
Claims124
A single-domain antibody comprising a set of complementarity determining regions (CDRs) comprising:
- (i) a CDR1 having the sequence as set forth in SEQ ID NO:
- 117, a CDR2 having the sequence as set forth in SEQ ID NO:
- 118, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 119;
- (ii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 120, a CDR2 having the sequence as set forth in SEQ ID NO:
- 121, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 122;
- (iii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 123, a CDR2 having the sequence as set forth in SEQ ID NO:
- 124, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 125;
- (iv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 126, a CDR2 having the sequence as set forth in SEQ ID NO:
- 127, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 128;
- (v) a CDR1 having the sequence as set forth in SEQ ID NO:
- 129, a CDR2 having the sequence as set forth in SEQ ID NO:
- 130, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 131;
- (vi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 132, a CDR2 having the sequence as set forth in SEQ ID NO:
- 133, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 134;
- (vii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 135, a CDR2 having the sequence as set forth in SEQ ID NO:
- 136, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 137;
- (viii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 138, a CDR2 having the sequence as set forth in SEQ ID NO:
- 139, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 140;
- (ix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 141, a CDR2 having the sequence as set forth in SEQ ID NO:
- 142, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 143;
- (x) a CDR1 having the sequence as set forth in SEQ ID NO:
- 144, a CDR2 having the sequence as set forth in SEQ ID NO:
- 145, and a CDRH3 having the sequence as set forth
- (xi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 147, a CDR2 having the sequence as set forth in SEQ ID NO:
- 148, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 149;
- (xii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 150, a CDR2 having the sequence as set forth in SEQ ID NO:
- 151, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 152;
- (xiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 153, a CDR2 having the sequence as set forth in SEQ ID NO:
- 154, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 155;
- (xiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 156, a CDR2 having the sequence as set forth in SEQ ID NO:
- 157, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 158;
- (xv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 159, a CDR2 having the sequence as set forth in SEQ ID NO:
- 160, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 161;
- (xvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 162, a CDR2 having the sequence as set forth in SEQ ID NO:
- 163, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 164;
- (xvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 165, a CDR2 having the sequence as set forth in SEQ ID NO:
- 166, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 167;
- (xviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 168, a CDR2 having the sequence as set forth in SEQ ID NO:
- 169, and a CDRH3 having the sequence as set forth in SEQ ID NO:170;
- (xix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 171, a CDR2 having the sequence as set forth in SEQ ID NO:
- 139, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 173;
- (xx) a CDR1 having the sequence as set forth in SEQ ID NO:
- 174, a CDR2 having the sequence as set forth in SEQ ID NO:
- 175, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 176;
- (xxi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 177, a CDR2 having the sequence as set forth in SEQ ID NO:
- 178, and a CDRH3 having the sequence as set forth
- (xxii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 180, a CDR2 having the sequence as set forth in SEQ ID NO:
- 181, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 182;
- (xxiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 183, a CDR2 having the sequence as set forth in SEQ ID NO:
- 184, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 185;
- (xxiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 186, a CDR2 having the sequence as set forth in SEQ ID NO:
- 187, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 188;
- (xxv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 189, a CDR2 having the sequence as set forth in SEQ ID NO:
- 190, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 191;
- (xxvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 192, a CDR2 having the sequence as set forth in SEQ ID NO:
- 193, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 194;
- (xxvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 195, a CDR2 having the sequence as set forth in SEQ ID NO:
- 178, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 197;
- (xxviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 198, a CDR2 having the sequence as set forth in SEQ ID NO:
- 160, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 200;
- (xxix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 201, a CDR2 having the sequence as set forth in SEQ ID NO:
- 202, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 203;
- (xxx) a CDR1 having the sequence as set forth in SEQ ID NO:
- 204, a CDR2 having the sequence as set forth in SEQ ID NO:
- 205, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 206;
- (xxxi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 207, a CDR2 having the sequence as set forth in SEQ ID NO:
- 208, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 209;
- (xxxii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 210, a CDR2 having the sequence as set forth in SEQ ID NO:
- 211, and a CDRH3 having the sequence as set forth
- (xxxiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 213, a CDR2 having the sequence as set forth in SEQ ID NO:
- 214, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 215;
- (xxxiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 216, a CDR2 having the sequence as set forth in SEQ ID NO:
- 217, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 218;
- (xxxv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 120, a CDR2 having the sequence as set forth in SEQ ID NO:
- 220, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 221;
- (xxxvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 222, a CDR2 having the sequence as set forth in SEQ ID NO:
- 223, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 224;
- (xxxvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 225, a CDR2 having the sequence as set forth in SEQ ID NO:
- 226, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 227;
- (xxxviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 228, a CDR2 having the sequence as set forth in SEQ ID NO:
- 229, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 230;
- (xxxix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 231, a CDR2 having the sequence as set forth in SEQ ID NO:
- 232, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 233;
- (xI) a CDR1 having the sequence as set forth in SEQ ID NO:
- 234, a CDR2 having the sequence as set forth in SEQ ID NO:
- 235, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 236;
- (xIi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 237, a CDR2 having the sequence as set forth in SEQ ID NO:
- 238, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 239;
- (xIii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 240, a CDR2 having the sequence as set forth in SEQ ID NO:
- 241, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 242;
- (xIiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 243, a CDR2 having the sequence as set forth in SEQ ID NO:
- 244, and a CDRH3 having the sequence as set forth
- (xIiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 246, a CDR2 having the sequence as set forth in SEQ ID NO:
- 247, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 248;
- (xIv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 249, a CDR2 having the sequence as set forth in SEQ ID NO:
- 250, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 251;
- (xIvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 252, a CDR2 having the sequence as set forth in SEQ ID NO:
- 253, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 254;
- (xIvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 255, a CDR2 having the sequence as set forth in SEQ ID NO:
- 256, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 257;
- (xIviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 258, a CDR2 having the sequence as set forth in SEQ ID NO:
- 259, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 260;
- (xIix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 261, a CDR2 having the sequence as set forth in SEQ ID NO:
- 262, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 263;
- (I) a CDR1 having the sequence as set forth in SEQ ID NO:
- 264, a CDR2 having the sequence as set forth in SEQ ID NO:
- 265, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 266;
- (Ii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 129, a CDR2 having the sequence as set forth in SEQ ID NO:
- 268, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 269;
- (Iii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 270, a CDR2 having the sequence as set forth in SEQ ID NO:
- 271, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 272;
- (Iiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 273, a CDR2 having the sequence as set forth in SEQ ID NO:
- 274, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 275;
- (Iiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 276, a CDR2 having the sequence as set forth in SEQ ID NO:
- 277, and a CDRH3 having the sequence as set forth
- (Iv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 279, a CDR2 having the sequence as set forth in SEQ ID NO:
- 280, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 281;
- (Ivi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 282, a CDR2 having the sequence as set forth in SEQ ID NO:
- 283, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 284;
- (Ivii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 285, a CDR2 having the sequence as set forth in SEQ ID NO:
- 286, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 287;
- (Iviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 288, a CDR2 having the sequence as set forth in SEQ ID NO:
- 289, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 290;
- (Iix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 246, a CDR2 having the sequence as set forth in SEQ ID NO:
- 292, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 293;
- (Ix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 294, a CDR2 having the sequence as set forth in SEQ ID NO:
- 295, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 296;
- (Ixi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 297, a CDR2 having the sequence as set forth in SEQ ID NO:
- 298, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 299;
- (Ixii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 300, a CDR2 having the sequence as set forth in SEQ ID NO:
- 301, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 302;
- (Ixiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 303, a CDR2 having the sequence as set forth in SEQ ID NO:
- 304, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 305;
- (Ixiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 306, a CDR2 having the sequence as set forth in SEQ ID NO:
- 307, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 308;
- (Ixv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 309, a CDR2 having the sequence as set forth in SEQ ID NO:
- 310, and a CDRH3 having the sequence as set forth
- (Ixvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 312, a CDR2 having the sequence as set forth in SEQ ID NO:
- 313, and a CDRH3 having the sequence as set forth in SEQ ID NO:314;
- (Ixvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 315, a CDR2 having the sequence as set forth in SEQ ID NO:
- 316, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 317;
- (Ixviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 318, a CDR2 having the sequence as set forth in SEQ ID NO:
- 319, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 320;
- (Ixix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 321, a CDR2 having the sequence as set forth in SEQ ID NO:
- 322, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 323;
- (Ixx) a CDR1 having the sequence as set forth in SEQ ID NO:
- 324, a CDR2 having the sequence as set forth in SEQ ID NO:
- 325, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 326;
- (Ixxi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 327, a CDR2 having the sequence as set forth in SEQ ID NO:
- 328, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 329;
- (Ixxii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 330, a CDR2 having the sequence as set forth in SEQ ID NO:
- 331, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 332;
- (Ixxiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 270, a CDR2 having the sequence as set forth in SEQ ID NO:
- 193, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 335;
- (Ixxiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 318, a CDR2 having the sequence as set forth in SEQ ID NO:
- 337, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 338;
- (Ixxv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 339, a CDR2 having the sequence as set forth in SEQ ID NO:
- 340, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 341;
- (Ixxvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 282, a CDR2 having the sequence as set forth in SEQ ID NO:
- 343, and a CDRH3 having the sequence as set forth
- (Ixxvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 339, a CDR2 having the sequence as set forth in SEQ ID NO:
- 346, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 347;
- (Ixxviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 348, a CDR2 having the sequence as set forth in SEQ ID NO:
- 349, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 350;
- (Ixxix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 351, a CDR2 having the sequence as set forth in SEQ ID NO:
- 352, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 353;
- (Ixxx) a CDR1 having the sequence as set forth in SEQ ID NO:
- 354, a CDR2 having the sequence as set forth in SEQ ID NO:
- 355, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 356;
- (Ixxxi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 357, a CDR2 having the sequence as set forth in SEQ ID NO:
- 358, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 359;
- (Ixxxii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 360, a CDR2 having the sequence as set forth in SEQ ID NO:
- 361, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 362;
- (Ixxxiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 363, a CDR2 having the sequence as set forth in SEQ ID NO:
- 364, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 365;
- (Ixxxiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 366, a CDR2 having the sequence as set forth in SEQ ID NO:
- 367, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 368;
- (Ixxxv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 369, a CDR2 having the sequence as set forth in SEQ ID NO:
- 370, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 371;
- (Ixxxvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 372, a CDR2 having the sequence as set forth in SEQ ID NO:
- 373, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 374;
- (Ixxxvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 375, a CDR2 having the sequence as set forth in SEQ ID NO:
- 376, and a CDRH3 having the sequence as set forth
- (Ixxxviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 378, a CDR2 having the sequence as set forth in SEQ ID NO:
- 379, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 380;
- (Ixxxix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 381, a CDR2 having the sequence as set forth in SEQ ID NO:
- 382, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 383;
- (xc) a CDR1 having the sequence as set forth in SEQ ID NO:
- 384, a CDR2 having the sequence as set forth in SEQ ID NO:
- 385, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 386;
- (xci) a CDR1 having the sequence as set forth in SEQ ID NO:
- 387, a CDR2 having the sequence as set forth in SEQ ID NO:
- 388, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 389;
- (xcii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 390, a CDR2 having the sequence as set forth in SEQ ID NO:
- 391, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 392;
- (xciii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 387, a CDR2 having the sequence as set forth in SEQ ID NO:
- 394, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 395;
- (xciv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 396, a CDR2 having the sequence as set forth in SEQ ID NO:
- 397, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 398;
- (xcv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 399, a CDR2 having the sequence as set forth in SEQ ID NO:
- 400, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 401;
- (xcvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 402, a CDR2 having the sequence as set forth in SEQ ID NO:
- 403, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 404;
- (xcvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 396, a CDR2 having the sequence as set forth in SEQ ID NO:
- 406, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 407;
- (xcviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 408, a CDR2 having the sequence as set forth in SEQ ID NO:
- 409, and a CDRH3 having the sequence as set forth
- (xcix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 411, a CDR2 having the sequence as set forth in SEQ ID NO:
- 412, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 413;
- (c) a CDR1 having the sequence as set forth in SEQ ID NO:
- 414, a CDR2 having the sequence as set forth in SEQ ID NO:
- 415, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 416;
- (ci) a CDR1 having the sequence as set forth in SEQ ID NO:
- 417, a CDR2 having the sequence as set forth in SEQ ID NO:
- 418, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 419;
- (cii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 420, a CDR2 having the sequence as set forth in SEQ ID NO:
- 421, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 422;
- (ciii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 423, a CDR2 having the sequence as set forth in SEQ ID NO:
- 424, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 425;
- (civ) a CDR1 having the sequence as set forth in SEQ ID NO:
- 426, a CDR2 having the sequence as set forth in SEQ ID NO:
- 427, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 428;
- (cv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 429, a CDR2 having the sequence as set forth in SEQ ID NO:
- 430, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 431;
- (cvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 432, a CDR2 having the sequence as set forth in SEQ ID NO:
- 433, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 434;
- (cvii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 435, a CDR2 having the sequence as set forth in SEQ ID NO:
- 436, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 437;
- (cviii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 438, a CDR2 having the sequence as set forth in SEQ ID NO:
- 439, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 440;
- (cix) a CDR1 having the sequence as set forth in SEQ ID NO:
- 441, a CDR2 having the sequence as set forth in SEQ ID NO:
- 442, and a CDRH3 having the sequence as set forth
- (cx) a CDR1 having the sequence as set forth in SEQ ID NO:
- 444, a CDR2 having the sequence as set forth in SEQ ID NO:
- 445, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 446;
- (cxi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 429, a CDR2 having the sequence as set forth in SEQ ID NO:
- 448, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 449;
- (cxii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 429, a CDR2 having the sequence as set forth in SEQ ID NO:
- 451, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 452;
- (cxiii) a CDR1 having the sequence as set forth in SEQ ID NO:
- 453, a CDR2 having the sequence as set forth in SEQ ID NO:
- 454, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 455;
- (cxiv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 456, a CDR2 having the sequence as set forth in SEQ ID NO:
- 457, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 458;
- (cxv) a CDR1 having the sequence as set forth in SEQ ID NO:
- 459, a CDR2 having the sequence as set forth in SEQ ID NO:
- 460, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 461;
- or
- (cxvi) a CDR1 having the sequence as set forth in SEQ ID NO:
- 462, a CDR2 having the sequence as set forth in SEQ ID NO:
- 463, and a CDRH3 having the sequence as set forth in SEQ ID NO:
- 464,
- each according to Martin numbering.
451 more elements
A single-domain antibody comprising
- a sequence as set forth in:
- SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, SEQ ID NO:
- 26, SEQ ID NO:
- 27, SEQ ID NO:
- 28, SEQ ID NO:
- 29, SEQ ID NO:
- 30, SEQ ID NO:
- 31, SEQ ID NO:
- 32, SEQ ID NO:
- 33, SEQ ID NO:
- 34, SEQ ID NO:
- 35, SEQ ID NO:
- 36, SEQ ID NO:
- 37, SEQ ID NO:
- 38, SEQ ID NO:
- 39, SEQ ID NO:
- 40, SEQ ID NO:
- 41, SEQ ID NO:
- 42, SEQ ID NO:
- 43, SEQ ID NO:
- 44, SEQ ID NO:
- 45, SEQ ID NO:
- 46, SEQ ID NO:
- 47, SEQ ID NO:
- 48, SEQ ID NO:
- 49, SEQ ID NO:
- 50, SEQ ID NO:
- 51, SEQ ID NO:
- 52, SEQ ID NO:
- 53, SEQ ID NO:
- 54, SEQ ID NO:
- 55, SEQ ID NO:
- 56, SEQ ID NO:
- 57, SEQ ID NO:
- 58, SEQ ID NO:
- 59, SEQ ID NO:
- 60, SEQ ID NO:
- 61, SEQ ID NO:
- 62, SEQ ID NO:
- 63, SEQ ID NO:
- 64, SEQ ID NO:
- 65, SEQ ID NO:
- 66, SEQ ID NO:
- 67, SEQ ID NO:
- 68, SEQ ID NO:
- 69, SEQ ID NO:
- 70, SEQ ID NO:
- 71, SEQ ID NO:
- 72, SEQ ID NO:
- 73, SEQ ID NO:
- 74, SEQ ID NO:
- 75, SEQ ID NO:
- 76, SEQ ID NO:
- 77, SEQ ID NO:
- 78, SEQ ID NO:
- 79, SEQ ID NO:
- 80, SEQ ID NO:
- 81, SEQ ID NO:
- 82, SEQ ID NO:
- 83, SEQ ID NO:
- 84, SEQ ID NO:
- 85, SEQ ID NO:
- 86, SEQ ID NO:
- 87, SEQ ID NO:
- 88, SEQ ID NO:
- 89, SEQ ID NO:
- 90, SEQ ID NO:
- 91, SEQ ID NO:
- 92, SEQ ID NO:
- 93, SEQ ID NO:
- 94, SEQ ID NO:
- 95, SEQ ID NO:
- 96, SEQ ID NO:
- 97, SEQ ID NO:
- 98, SEQ ID NO:
- 99, SEQ ID NO:
- 100, SEQ ID NO:
- 101, SEQ ID NO:
- 102, SEQ ID NO:
- 103, SEQ ID NO:
- 104, SEQ ID NO:
- 105, SEQ ID NO:
- 106, SEQ ID NO:
- 107, SEQ ID NO:
- 108, SEQ ID NO:
- 109, SEQ ID NO:
- 110, SEQ ID NO:
- 111, SEQ ID NO:
- 112, SEQ ID NO:
- 113, SEQ ID NO:
- 114, SEQ ID NO:
- 115, SEQ ID NO:
- 116, SEQ ID NO:
- 509, SEQ ID NO:
- 510, SEQ ID NO:
- 511, SEQ ID NO:
- 512, SEQ ID NO:
- 513, SEQ ID NO:
- 514, SEQ ID NO:
- 515, SEQ ID NO:
- 516, SEQ ID NO:
- 517, SEQ ID NO:
- 518, SEQ ID NO:
- 519, SEQ ID NO:
- 520, SEQ ID NO:
- 521, SEQ ID NO:
- 522, SEQ ID NO:
- 523, SEQ ID NO:
- 524, or SEQ ID NO:
- 525;
- or
- a sequence having at least 90% sequence identity to a sequence as set forth in:
- SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, SEQ ID NO:
- 26, SEQ ID NO:
- 27, SEQ ID NO:
- 28, SEQ ID NO:
- 29, SEQ ID NO:
- 30, SEQ ID NO:
- 31, SEQ ID NO:
- 32, SEQ ID NO:
- 33, SEQ ID NO:
- 34, SEQ ID NO:
- 35, SEQ ID NO:
- 36, SEQ ID NO:
- 37, SEQ ID NO:
- 38, SEQ ID NO:
- 39, SEQ ID NO:
- 40, SEQ ID NO:
- 41, SEQ ID NO:
- 42, SEQ ID NO:
- 43, SEQ ID NO:
- 44, SEQ ID NO:
- 45, SEQ ID NO:
- 46, SEQ ID NO:
- 47, SEQ ID NO:
- 48, SEQ ID NO:
- 49, SEQ ID NO:
- 50, SEQ ID NO:
- 51, SEQ ID NO:
- 52, SEQ ID NO:
- 53, SEQ ID NO:
- 54, SEQ ID NO:
- 55, SEQ ID NO:
- 56, SEQ ID NO:
- 57, SEQ ID NO:
- 58, SEQ ID NO:
- 59, SEQ ID NO:
- 60, SEQ ID NO:
- 61, SEQ ID NO:
- 62, SEQ ID NO:
- 63, SEQ ID NO:
- 64, SEQ ID NO:
- 65, SEQ ID NO:
- 66, SEQ ID NO:
- 67, SEQ ID NO:
- 68, SEQ ID NO:
- 69, SEQ ID NO:
- 70, SEQ ID NO:
- 71, SEQ ID NO:
- 72, SEQ ID NO:
- 73, SEQ ID NO:
- 74, SEQ ID NO:
- 75, SEQ ID NO:
- 76, SEQ ID NO:
- 77, SEQ ID NO:
- 78, SEQ ID NO:
- 79, SEQ ID NO:
- 80, SEQ ID NO:
- 81, SEQ ID NO:
- 82, SEQ ID NO:
- 83, SEQ ID NO:
- 84, SEQ ID NO:
- 85, SEQ ID NO:
- 86, SEQ ID NO:
- 87, SEQ ID NO:
- 88, SEQ ID NO:
- 89, SEQ ID NO:
- 90, SEQ ID NO:
- 91, SEQ ID NO:
- 92, SEQ ID NO:
- 93, SEQ ID NO:
- 94, SEQ ID NO:
- 95, SEQ ID NO:
- 96, SEQ ID NO:
- 97, SEQ ID NO:
- 98, SEQ ID NO:
- 99, SEQ ID NO:
- 100, SEQ ID NO:
- 101, SEQ ID NO:
- 102, SEQ ID NO:
- 103, SEQ ID NO:
- 104, SEQ ID NO:
- 105, SEQ ID NO:
- 106, SEQ ID NO:
- 107, SEQ ID NO:
- 108, SEQ ID NO:
- 109, SEQ ID NO:
- 110, SEQ ID NO:
- 111, SEQ ID NO:
- 112, SEQ ID NO:
- 113, SEQ ID NO:
- 114, SEQ ID NO:
- 115, SEQ ID NO:
- 116, SEQ ID NO:
- 509, SEQ ID NO:
- 510, SEQ ID NO:
- 511, SEQ ID NO:
- 512, SEQ ID NO:
- 513, SEQ ID NO:
- 514, SEQ ID NO:
- 515, SEQ ID NO:
- 516, SEQ ID NO:
- 517, SEQ ID NO:
- 518, SEQ ID NO:
- 519, SEQ ID NO:
- 520, SEQ ID NO:
- 521, SEQ ID NO:
- 522, SEQ ID NO:
- 523, SEQ ID NO:
- 524, or SEQ ID NO:
- 525.
268 more elements
The HcAb of claim 39, wherein the multimer is an IgM multimer, an IgA multimer, or an IgG multimer.
Dependencies are inferred from the claim text.