US 2023/0331769 A1Published application

Method for extending half-life of a protein

AssigneeUbiprotein, Corp.

InventorsKyunggon Kim, Kwang-Hyun Baek, Sung-Ryul Bae, Myung-Sun Kim, Hyeonmi Kim, Yeeun Yoo, Lan Li, Jung-Hyun Park, Jin-Ok Kim

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Abstract

The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.

Claims4

Dependent claims

A GLP-1 having a prolonged half-life, wherein the GLP-1 has amino acid sequences of SEQ ID NO:

89, and one or more lysine residue(s) at positions corresponding to 117 and 125 from the N-terminus of the GLP-1 are replaced by arginine(s).

Dependencies are inferred from the claim text.

Facts

Application: 17/990,460Filed 18 Nov 2022
Priority: KR 10-2015-016072816 Nov 2015
Published: 19 Oct 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification41 codes

C07K 1/1075
By covalent attachment of residues or functional groups: by covalent attachment of amino acids or peptide residues
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 5/04
Of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin: for decreasing, blocking or antagonising the activity of the hypothalamic…

Family

Application15/776,680Division · filed 16 May 2018
Application17/990,460Division
US 2019/0382439 A1Published application
US 2023/0331769 A1This patent

From the US filing history. Foreign family members aren’t listed.

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