Compositions and methods for inhibiting vascular smooth muscle cell proliferation
OwnerFrank Rutsch, David Thompson +2inventors
InventorsFrank Rutsch, David Thompson, Yvonne Nitschke, Robert Terkeltaub
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Abstract
The present disclosure provides compositions and methods for treating vascular smooth muscle cell proliferation in a subject that does not have a deficiency of ectonucleotide pyrophosphatase phosphodiesterase-1 (ENPP1) resulting in a pathological disease of calcification or ossification by administering an ENPP1 agent or an ENPP3 agent.
Claims31
1-149. (canceled)
An arterial stent coated with an ENPP1 or ENPP3 agent for reducing and/or preventing progression of vascular smooth muscle cell proliferation in a subject having a tissue injury or in a subject who has a condition requiring surgery at a surgical site, wherein said stent is implanted into an artery of the subject proximal to said tissue injury or said surgical site, and wherein said implanted stent is configured to release said ENPP1 or ENPP3 agent in an amount effective to reduce and/or prevent progression of vascular smooth muscle cell proliferation at the site of injury or the surgical site in the subject.
A method for reducing and/or preventing progression of vascular smooth muscle cell proliferation in a subject having a tissue injury or a subject who has a condition requiring surgery at a surgical site, said method comprising:
- administering to the subject an amount of an ENPP1 or ENPP3 agent effective to reduce and/or prevent progression of vascular smooth muscle cell proliferation at the site of injury or the surgical site in the subject.
Dependencies are inferred from the claim text.