Materials and methods for suppressing and/or treating bone related diseases and symptoms
AssigneesIndiana University Research and Technology Corporation, University of Rochester, The United States of America As Represented by the Department of Veterans Affairs Office of General
InventorsTeresita M. Bellido, G. David Roodman, Jesus Delgado-Calle, Robert K. Boeckman, Frank H. Ebetino
Life of this patent
Estimating the term…
Abstract
Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.
Claims25
A compound comprising:
- a compound of the formula A-Y-B;
- wherein:
- A is at least one agent that reduces and/or inhibits the activitiy of gamma-secretase;
- B is at least one bone-targeting molecule;
- and
- Y is a linker that joins and/or links A and B;
- or a pharmaceutically acceptable salt thereof, or a metabolite thereof.
The compound according to any of the preceding claims, wherein said compound is a compound of formula:
- or a pharmaceutically acceptable salt thereof, or a metabolite thereof.
A method of treating a bone related disease, comprising the steps of:
- administering to a subject at least one therapeutically effective dose of at least one agent that reduces and/or inhibits the activitiy of gamma-secretase, or a pharmaceutically acceptable salt or metabolite thereof, and at least one bisphosphonate, or a pharmaceutically acceptable salt or metabolite thereof.
Dependencies are inferred from the claim text.