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US 2023/0330102 A1Published application
Protac antibody conjugates and methods of use
AssigneeGenentech, Inc.
InventorsThomas Pillow, Jack Sadowsky, Leanna Staben, Steven Staben, Binqing Wei, Ingrid Wertz, Pragya Adhikari, Nicole Blaquiere, Peter Dragovich, Wayne Fairbrother
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Abstract
The subject matter described herein is directed to antibody-PROTAC conjugates (PACs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.
Claims46
A conjugate having the chemical structure
- Ab-(L1-D)p,
- wherein,
- D is a PROTAC having the structure E3LB-L2-PB;
- E3LB is an E3 ligase binding group covalently bound to L2;
- L2 is a linker covalently bound to E3LB and PB;
- PB is a protein binding group covalently bound to L2;
- Ab is an antibody covalently bound to L1;
- L1 is a linker, covalently bound to Ab and D;
- and
- p has a value from about 1 to about 8.
7 more elements
Dependencies are inferred from the claim text.