Device for cardiac electrophysiology procedure

A control unit (150), an operating modus of the control unit (150), wherein said operating modus is a mapping modus of the control unit which provides the electronic mapping of the arrhythmic substrate comprising a plurality of steps:

• to set and change the setting of the value of the resistor (151) so that the current can be recorded by the sensor device (160) and may be configured to be maximal;
• to process a set of measurement data provided from the sensor device (160) wherein the improvement comprises the measurement of the value of the instantaneous differential resistance, wherein the control unit is configured to display the set of measurement data at a display;
• to control the first selector switch (156) and the second selector switch (155) during mapping, optionally but not necessarily dependent on the cardiac signal, wherein the setting of the second selector switch and the setting of the first selector switch may be set to be different so that the sensor device is said to operate in a bipolar mode and wherein the setting of the second selector switch and the setting of the first selector switch may be set to be the same so that the sensor device is said to operate in an unipolar mode;
• to set and to change the setting of the second selector switch (155), such that the resistor (151) is sequentially connected to a plurality of selected active electrodes in a bipolar mode if the value of the differential resistance provided by the sensor device is or turns negative during mapping, wherein this may indicate that the selected active electrode according to the setting of the first selecting switch is approaching or in electromechanical coupling to the arrhythmic substrate;
• to set and to change the setting of the second selector switch (155), such that the resistor (151) is sequentially connected to a plurality of selected active electrodes in a bipolar mode provided that the value of the differential resistance provided by the sensor device is and remains negative regardless of the setting of the second selector switch (155), wherein this may indicate stability of the selective active electrode according to the setting of the first selector switch in stabile electromechanical coupling to the arrhythmic substrate;
• to alter the setting of the first selector switch (156) to the selective active electrode most suitable according to the three dimensional architecture of the mapping catheter for the electrophysiology therapy, preferably but not limited to one of the tip or central electrodes of the mapping catheter, provided that the selective active electrode most suitable according to the three dimensional architecture of the mapping catheter for the electrophysiology therapy is now set by mapping manoeuvres in stable electromechanical coupling with the arrhythmic substrate, wherein the stability of the selective active electrode now in electromechanical coupling with the arrhythmic substrate and according to the new setting of the first selector switch is provided and may allow the electrophysiology therapy, wherein the value of the differential resistance provided by the sensor device (160) turns equal or greater than zero during the electrophysiology therapy;
• to change the setting of the second selector switch to a plurality of positions in a bipolar mode, provided that the value of the differential resistance provided by the sensor device is and remains equal or greater than zero despite changing the setting of the second selector switch to a plurality of positions in a bipolar mode, wherein this may allow the discontinuation of the electrophysiology therapy,
• wherein the entire sequence above may be repeated through mapping manoeuvres to map point by point the entire arrhythmic substrate;
• to automatically change the setting of the second selector switch (155), such that the neutral electrode (170) is sequentially connected via the resistor (151) to a plurality of active electrodes in a bipolar mode if the value of the differential resistance provided by the sensor device has a specific value, either negative, zero or positive;
• to automatically set and change the setting of the first selector switch and of the second selector switch in a bipolar or in an unipolar mode during mapping at a customised switching rate.

A therapy of an arrhythmia comprising the following steps:

• the passage of a staining ink through the internal lumen of the mapping catheter connected to the catheter device (110) or optionally through the internal lumen od an additional mapping catheter suitable positioned in electromechanical coupling to the arrhythmic substrate only for the therapy;
• the delivery of the staining ink to the arrhythmic substrate;
• the ink staining of the arrhythmic substrate with the staining ink,
• wherein
• the therapy is an electrophysiology therapy (EPT) and not an ablation of the arrhythmic substrate,
• wherein the electrophysiology therapy (EPT) restores the electronic properties of the arhythmic substrate,
• wherein
• the staining ink is a potentiometric ink,
• wherein
• the staining ink is an organic semiconductor ink,
• wherein
• the staining ink is a lipophilic or oxidised lipophilic ink
• wherein
• the staining ink is configured to be a straight-chain or a branched-chain carbohydrate, a carbocycle or heterocycle containing ink,
• wherein
• the staining ink is a polymeric ink,
• wherein
• the staining ink is a conductive polymeric ink,
• wherein
• the staining ink is a magnetic ink,
• wherein
• the staining ink is a combination of the above staining inks,
• wherein
• the staining ink is chosen to be dissolvable,
• wherein
• the staining ink contains soluble graphene,
• wherein
• the staining ink non.invasively integrates into the arrhythmic substrate
• wherein
• the dissolvable staining ink is conformal with the arrhythmic substrate.