Ca ix - nir dyes and their uses
AssigneeOn Target Laboratories, LLC
InventorsSumith A. Kularatne, Mini Thomas
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Abstract
The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
Claims20
A composition comprising a first compound, or salt thereof and a second compound, or salt thereof, wherein the first compound has a formula
- wherein B is a CA IX-targeted molecule is selected from the group consisting of
- and
- wherein n is 0, 1, 2, or 3;
- m is 0, 1, 2, 3, 4, or 5, and p is 0, 1, 2, or 3;
- W comprises an extended hydrophobic residue;
- X comprises a hydrophobic spacer;
- Y comprises an amino acid spacer;
- and
- Z comprises a NIR dye;
- and wherein the second compound comprises an NIR dye and pteroyl ligand conjugated to an amino acid linking group or a PSMA-targeting compound conjugated to an amino acid linking group.
Dependencies are inferred from the claim text.