Recombinant microorganisms
AssigneesAcademia Sinica, The Regents of the University of California
InventorsYu-Hsiao Chen, Hsin-Wei Jung, Chao-Yin Tsuei, James C. Liao
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Abstract
Provided herein are metabolically-modified microorganisms that can grow on an organic C1 carbon source.
Claims19
A synthetic methylotroph (SM) that grows on methanol as a sole carbon source and has a doubling time (tD) of less than 12 hours.
A synthetic methylotroph designated Escherichia coli SM1 having ATCC accession no. PTA-126783.
A recombinant microorganism that grows on methanol and expresses:
- a polypeptide having methanol dehydrogenase activity,
- a polypeptide having hexulose-6-phosphate synthase activity,
- a polypeptide having hexulose-6-phosphate isomerase activity and
- comprises increased activity of a polypeptide having phosphoglucoisomerase activity.
A recombinant microorganism that assimilates a C1 carbon source and comprises a plurality of enzymes selected from the group consisting of Medh, Hps, Phi, Pgi, RpiA, Tkt, Tal and any combination thereof.
Dependencies are inferred from the claim text.