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US 2023/0312465 A1Published application
A process for preparation of clethodim
AssigneeUpl Ltd
InventorsRakesh Bhikubhai Patel, Digish Manubhai Panchal
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Abstract
The present invention provides a process for the preparation of clethodim by reacting 5-[2-(ethylthio)propyl]-2-(1-oxopropyl)-1,3-cyclohexanedione with O-(3-chloro-2-propen-1-yl)hydroxylamine in the absence of a solvent. A continuous flow process for preparing clethodim is also provided.
Claims10
A process for the preparation of clethodim of formula (I)
- by reacting 5-[2-(ethylthio)propyl]-2-(1-oxopropyl)-1,3-cyclohexanedione of formula (II)
- with O-(3-chloro-2-propen-1-yl)hydroxylamine of formula (III)
- in the absence of a solvent.
A continuous flow process for preparing clethodim, said process comprising:
- a) charging 5-[2-(ethylthio)propyl]-2-(1-oxopropyl)-1,3-cyclohexanedione into a microreactor unit through a first dosing line;
- b) charging O-(3-chloro-2-propen-1-yl) hydroxylamine into the microreactor unit through a second dosing line;
- c) reacting 5-[2-(ethylthio)propyl]-2-(1-oxopropyl)-1,3-cyclohexanedione with O-(3-chloro-2-propen-1-yl) hydroxylamine in the absence of a solvent in a microreactor.
Clethodim produced by a process comprising reacting 5-[2-(ethylthio)propyl]-2-(1-oxopropyl)-1,3-cyclohexanedione with O-(3-chloro-2-propen-1-yl)hydroxylamine (III) in the absence of a solvent.
Dependencies are inferred from the claim text.