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US 2023/0310709 A1Published application
Retinal graft and method of preparation
AssigneePrecise Bio 3D LTD
InventorsAmos EITAN, Aryeh Batt, Ariel Eisenbach, Dorin Sade Yazdi, Michal Marcus, Lior Rosenberg Belmaker, Maayan Malki, Gal Shenbach-Koltin
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Abstract
A method of manufacturing a retinal graft. The method includes: (a) preparing a scaffold material solution; (b) air-drying the scaffold material solution, to form a thin scaffold layer; (c) crosslinking the thin scaffold layer; (d) rehydrating the scaffold layer; and (e) applying retinal pigment epithelium cells onto the scaffold layer.
Claims35
A retinal graft comprising:
- a scaffold layer made of a rehydrated crosslinked scaffold layer;
- and
- at least one matured layer of retinal pigment epithelium, RPE, cells on top or within said scaffold layer;
- wherein said scaffold layer was initially dried and only then crosslinked before said at least one matured layer of RPE cells are position on top or within said scaffold layer.
1 more element
A method of manufacturing a retinal graft, said method comprising:
- preparing a scaffold material solution;
- air-drying the scaffold material solution, to form a thin scaffold layer;
- crosslinking the thin scaffold layer;
- rehydrating the scaffold layer;
- and
- applying retinal pigment epithelium cells onto the scaffold layer.
3 more elements
Dependencies are inferred from the claim text.