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US 2023/0305014 A1Published application
Methods of determining risk of and treating cancer recurrence
AssigneeThe Regents of the University of Michigan
InventorHoward Petty
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Abstract
Provided herein are systems and methods for the prediction of recurrent cancer in a subject and systems and methods for using the prediction in the treatment or prevention of cancer recurrence.
Claims32
A method comprising:
- determining intracellular localization of at least one biomarker for cancer recurrence in a sample comprising cancer cells from a subject;
- and
- predicting cancer recurrence in a subject.
A method for distinguishing recurrent from non-recurrent cancer comprising determining intracellular localization of a biomarker for cancer recurrence in a sample comprising cancer cells,
- wherein the biomarker for cancer recurrence is selected from the group consisting of:
- phosphorylated glucose transporter type 1;
- transketolase-like protein-1;
- glutathione synthetase;
- GTP-loaded RhoA;
- RhoA;
- and any combination thereof.
4 more elements
A system comprising at least one or all of:
- a primary antibody to a biomarker for cancer recurrence;
- an imaging instrument;
- and
- software configured to determine the intracellular location of the biomarker for cancer recurrence;
- and
- optionally, a sample.
3 more elements
A method comprising:
- (a) obtaining a sample from a subject;
- and
- (b) determining intracellular localization of one or more biomarkers selected from phosphorylated glucose transporter type 1, transketolase-like protein-1, glutathione synthetase, GTP-loaded RhoA, and RhoA in cells from the sample.
Dependencies are inferred from the claim text.