Intratumoral vaccination
AssigneeHeat Biologics, Inc.
InventorsSuresh DE SILVA, Taylor SCHREIBER
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Abstract
The present disclosure relates to, inter alia, a method for treating a tumor by intratumorally delivering an effective amount of a composition comprising an expression vector that comprises a first nucleotide sequence encoding a secretable vaccine protein, and a second nucleotide sequence encoding a T cell costimulatory fusion protein.
Claims20
A method for treating a tumor in a subject in need thereof, comprising intratumorally delivering an effective amount of a composition comprising an expression vector that comprises a first nucleotide sequence encoding a secretable qp96-immunoqlobulin (qp96-lq) fusion protein which lacks the qp96 KDEL (SEQ ID NO:
- 3) sequence, and a second nucleotide sequence encoding a T cell costimulatory fusion protein.
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Dependencies are inferred from the claim text.