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US 2023/0302146 A1Published application
Hybrid carriers for nucleic acid cargo
AssigneeCureVac AG
InventorsPatrick BAUMHOF, Carolin THIELE, Joanna REJMAN
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Abstract
A composition for the delivery of a nucleic acid compound is provided which comprises a cationic peptide or polymer and a lipidoid compound. The nucleic acid compound may be any chemically modified or unmodified DNA or RNA. The amount of the lipidoid in the composition is preferably low, relative to the cationic peptide or polymer.
Claims25
A composition comprising:
- (a) a cationic peptide or polymer;
- (b) a cationic or permanent lipidoid compound;
- and
- (c) a nucleic acid compound;
- wherein the cationic or permanent cationic lipidoid compound comprises two or three moieties of formula IIa and/or formula IIb:
- —N(R1)—CH2—CH(R5)—R2 (formula IIa)
- —N+(R3)(R4)—CH2—CH(R5)—R2 (formula IIb)
- wherein independently for each individual moiety of formula IIa or formula IIb
- R1 is selected from hydrogen or C1-C4-alkyl,
- R2 is selected from linear or branched, saturated or unsaturated C6-C16 hydrocarbyl chain,
- R3 and R4 are selected from C1-C4-alkyl, and
- R5 is hydrogen or hydroxyl.
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Dependencies are inferred from the claim text.