Analogs of Nitrofuran Antibiotics to Combat Resistance

A compound of formula (I):

• wherein
• R1 is C6-C10 aryl, biaryl, or mono- or bicyclic heteroaryl, wherein each hydrogen atom in C6-C10 aryl, biaryl, or mono- or bicyclic heteroaryl is optionally substituted with halogen, —OR5, —NR5R6, —S(O)2NR5R6, or —N(R5)SO2R6;
• R2 is hydrogen;
• or R1 and R2 combine with the atoms to which they are attached to form a 3- to 7-membered heterocycloalkyl optionally substituted by oxo;
• R3 is C6-C10 aryl, biaryl, or mono- or bicyclic heteroaryl, wherein each hydrogen atom in C6-C10 aryl aryl, biaryl, and mono- or bicyclic heteroaryl is optionally substituted by -OR5 or nitro;
• R4 is hydrogen;
• R5 and R6 are each individually hydrogen, C1-C6 alkyl, C6-C10 aryl, or mono- or bicyclic heteroaryl, wherein each hydrogen atom in C1-C6 alkyl, C6-C10 aryl, and mono- or bicyclic heteroaryl is optionally substituted with halogen or -OC1-C6 alkyl;
• or a pharmaceutically acceptable salt thereof, provided the compound is not
• .