Collagen-polymer scaffold delivery system for periodontal repair and regeneration
AssigneeRvo 2.0, Inc. D/B/A Optics Medical
InventorsGabriel N. Njikang, Alan Ngoc Le, Beverly W. Lubit
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Abstract
The present disclosure provides a hydrogel composition comprising an interpenetrating polymer network (IPN) containing a biopolymer, a first synthetic polymer and a second synthetic polymer in which a contained community of live human MSCs is embedded. The collagen polymer matrix described (a) allows the embedded cells to remain in place or to migrate over short distances; (b) allows diffusion of small molecules, particularly growth factors produced by the cells or provided as a supplement, and EVs released by the cells to support the recovery of periodontium tissue function following injury.
Claims38
A periodontal implant configured into a physical form selected from a film, a fiber, a filament, a sheet, a thread, a cylindrical implant, an asymmetrically-shaped implant, a fibrous mesh, or an injectable gel, comprising an embedded population of at least 0.5×10*5 live cells;
- wherein the implant is fabricated from a hydrogel composition comprising a water content ranging from, e.g., 40% to 92% (w/w inclusive) sufficient to sustain nutritional transport;
- wherein the hydrogel composition comprises an interpenetrating polymer network containing a biopolymer and two synthetic polymers, the biopolymer is a collagen;
- and the synthetic polymers are 2-methacryloyloxyethyl phosphorylcholine (MPC) and poly(ethylene glycol)diacrylate (PEGDA);
- wherein the two synthetic polymers are at least partially interlaced on a molecular scale to form a polymer matrix but are not covalently bonded to each other and cannot be separated;
- wherein the periodontal implant is highly porous and biodegradable;
- and
- wherein the periodontal implant may support cell growth and permit the transportation of oxygen, nutrients and waste products.
A method for treating a site affected by periodontal disease comprising delivering locally by implant to an affected site an implant comprising an embedded population of at least 0.5×10*5 live cells;
- wherein the implant is fabricated from a hydrogel composition comprising a water content ranging from, e.g., 40% to 92% (w/w inclusive) sufficient to sustain nutritional transport;
- wherein the hydrogel composition comprises an interpenetrating polymer network containing a biopolymer and two synthetic polymers, the biopolymer is a collagen;
- and the synthetic polymers are 2-methacryloyloxyethyl phosphorylcholine (MPC) and poly(ethylene glycol)diacrylate (PEGDA);
- and
- wherein the two synthetic polymers are at least partially interlaced on a molecular scale to form a polymer matrix but are not covalently bonded to each other and cannot be separated;
- wherein the periodontal implant is highly porous and biodegradable;
- wherein the periodontal implant may support cell growth and permit the transportation of oxygen, nutrients and waste products;
- and
- wherein the periodontal implant may effect wound healing of the affected site.
Dependencies are inferred from the claim text.