Methods for treating and preventing cytomegalovirus infection
AssigneesLa Jolla Institute for Immunology, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsChristopher Benedict, Jeremy P. Kamil, Mohammed Nure Alam Siddiquey, Erica Ollmann Saphire, Michael Norris
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Abstract
Provided herein, inter alia, are compositions and methods for treating or preventing viral infections. The methods and compositions may modulate entry of a virus into a cell, viral fusion to a cell, or cell to cell spread of the virus by targeting one or more viral proteins or ligands thereof. The methods and compositions provided herein including embodiments thereof are contemplated to be especially effective for treating or preventing cytomegalovirus infections.
Claims59
A method of treating or preventing a cytomegalovirus (CMV) infection in a subject in need thereof, the method comprising administering to said subject a therapeutically or prophylactically effective amount of an agent that modulates a UL141/UL116/gH multimer.
A method of preventing a cytomegalovirus (CMV) infection in a subject in need thereof, the method comprising administering to said subject a prophylactically effective amount of an agent comprising UL141 or a fragment thereof.
A vaccine composition comprising UL141 or a fragment thereof and a pharmaceutically acceptable excipient.
A method for screening agents that inhibit cytomegalovirus (CMV) host cell entry, fusion of CMV with a host cell, or cell-to-cell spread of CMV, comprising administering a test agent to a CMV-receptive cell, administering CMV to said CMV-receptive cell, and determining whether said agent modulates a UL141/UL116/gH multimer.
A composition comprising an agent coupled to a diagnostic agent, wherein said agent binds a UL141/UL116/gH multimer.
A composition comprising a nucleic acid encoding a protein having at least 80% sequence identity to the amino acid sequence of SEQ ID NO:15, 16, 17, 20, 22, 23, 26, 28, or 31.
A composition comprising one or more nucleic acids provided herein, or proteins encoded by said nucleic acids.
Dependencies are inferred from the claim text.