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US 2023/0293658 A1Published application
Group a strep immunogenic compositions with polysaccharide-protein conjugates
AssigneeVaxcyte, Inc.
InventorsJeffery C. FAIRMAN, Neeraj KAPOOR, Peter T. DAVEY, Angie A. SEDRA
Life of this patent
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Abstract
The present disclosure provides immunogenic compositions comprising Group A Streptococcus (GAS) polypeptide antigens and at least one polypeptide-polysaccharide conjugate. The present disclosure further provides methods of using such compositions to induce immune responses against GAS infections in subjects.
Claims55
An immunogenic composition comprising
- a. a first Group A Streptococcus (GAS) polypeptide antigen;
- b. a second GAS polypeptide antigen;
- and
- c. at least one polypeptide-polysaccharide conjugate, wherein the conjugate polypeptide is a third GAS polypeptide antigen or a non-GAS carrier polypeptide and comprises at least one non-natural amino acid, and wherein the conjugate polysaccharide is a GAS polysaccharide or a variant thereof that lacks an immunodominant N-acetyl Glucosamine (GlcNAc) side chain.
1 more element
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15-16. (canceled)
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An immunogenic composition comprising
- a. a Group A Streptococcus (GAS) C5a peptidase polypeptide antigen;
- b. a GAS streptolysin O (SLO) polypeptide antigen;
- and
- c. a polypeptide-polysaccharide conjugate comprising a Streptococcus pyogenes Adhesion and Division (SpyAD) conjugate polypeptide and a GAS conjugate polysaccharide or a variant thereof that lacks an immunodominant N-acetyl Glucosamine (GlcNAc) side chain.
1 more element
An immunogenic composition comprising
- a. a Group A Streptococcus (GAS) C5a peptidase polypeptide antigen;
- b. a GAS streptolysin O (SLO) polypeptide antigen;
- and
- c. a polypeptide-polysaccharide conjugate comprising an arginine deiminase (ADI) conjugate polypeptide and a GAS conjugate polysaccharide or a variant thereof that lacks an immunodominant N-acetyl Glucosamine (GlcNAc) side chain.
1 more element
An immunogenic composition comprising
- a. a Group A Streptococcus (GAS) C5a peptidase polypeptide antigen;
- b. a GAS streptolysin O (SLO) polypeptide antigen;
- and
- c. a polypeptide-polysaccharide conjugate comprising a ferritin polypeptide and a GAS conjugate polysaccharide or a variant thereof that lacks an immunodominant N-acetyl Glucosamine (GlcNAc) side chain.
1 more element
54-57. (canceled)
Dependencies are inferred from the claim text.