Back to results
US 2023/0287494 A1Published application
Methods for screening embryos
OwnerShahryar K. KAVOUSSIinventor
Life of this patent
Estimating the term…
Abstract
Methods of assessing obstetric outcomes of embryos based on the expression of pappalysin-1 (PAPPA), e.g., as measured in a biopsy from an embryo at the blastocyst stage, blastocoel fluid, or embryo culture conditioned media, are provided.
Claims26
An in vitro method of screening an embryo, comprising:
- (i) obtaining in vitro an embryo at the blastocyst stage of development, and
- (ii) measuring the expression of pregnancy-associated plasma protein-A (PAPPA) in one or more embryo cells, in the blastocoel fluid, and/or in embryo culture fluid that has been used to store or culture the embryo;
- wherein a decreased expression of PAPPA below a control level indicates an increased risk of an adverse obstetric outcome if the embryo is implanted into a mammalian subject.
Dependencies are inferred from the claim text.