Heterocyclic compounds useful in the treatment of disease

A compound having the structure of Formula I

• or a pharmaceutically acceptable salt thereof,
• wherein RA is —CO2H, tetrazolyl, —C(═O)NH2, —C(═O)NHRB, —CONHCN, —C(═O)NHSO2RB or —C(═O)NHCH2CH2SO3H;
• RB is a substituted or unsubstituted C1-C4 alkyl;
• L1 is a substituted or unsubstituted saturated C1-C6 alkylene, or L1 is —CH2—,
• or dimethylmethane;
• A1 is N or C;
• Ring A has the structure of one of:
• RC is —CN, —F, —Cl, or C1-C4 fluoroalkyl;
• RD is —N(RF)—C(═O)XCH(RG)—CY, wherein X is O and CY is unsubstituted phenyl or Phenyl substituted with one RH:
• RE, RF and RG independently are —H or saturated C1-C4 alkyl or RE and RF independently are —H or saturated C1-C4 alkyl and one RG is saturated —C1-C4 alkyl and is taken together with the RH phenyl moiety of the Ring A RD substituent and the carbon atom to which RG and said phenyl moiety is attached to define a substituted or unsubstituted carbocycle, and the other RG, if present, is as defined for RE;
• and
• each RH is independently absent, a halogen, or substituted or unsubstituted saturated C1-C4 alkyl.