Polysaccharide derivative, polysaccharide derivative-drug conjugate, and method for producing same
AssigneesThe University of Tokyo, Mochida Pharmaceutical Co., Ltd.
InventorsTaichi ITO, Seiichi OHTA, Pan QI, Arvind Kumar Singh CHANDEL, Mitsuko ISAJI
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Abstract
To provide a novel polysaccharide derivative which can be used to form a conjugate with a drug and can be used as a medical material, and a polysaccharide derivative-drug conjugate which uses the same. A polysaccharide derivative obtained by introducing a group represented by formula (A) to a polysaccharide which is acidic, basic or both, and a polysaccharide derivative-drug conjugate of said polysaccharide derivative and a drug.
Claims25
A polysaccharide derivative obtained by introducing a group represented by formula (A) below into a polysaccharide which is acidic, basic or amphoteric:
- in the formula, R1 represents a hydrogen atom or C1-4 alkyl,
- ring P is a phenyl ring or pyridine ring, and the phenyl ring or pyridine ring is optionally substituted with one or more substituents independently selected from the halogen atoms and —CF3, —NO2, carboxyl and —SO3H groups,
- Y represents a divalent group selected from the group consisting of —NH—, —C(═O)—, —S—, —O—, the C1-6 alkylenes and —(CH2CH2O)n— and any combinations of these, with n being an integer from 1 to 9, and
- * represents a linkage with the polysaccharide.
Dependencies are inferred from the claim text.