Methods and compositions for treating cancer
AssigneeOmeros Corporation
InventorsGeorge A. Gaitanaris, Marc A. Gavin, Robert H. Lemus, Caglar Cekic, Mohammed Oukka, Trupti Vardam-Kaur
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Abstract
Compounds, compositions, and methods for generating T cells with altered phenotype are disclosed. The phenotype-altered T cells have increased persistence, prolonged survival, and increased antitumor activity and are useful for treatment of cancers.
Claims29
A method for treating a disease, comprising administering to a subject in need thereof a therapeutically effective amount of phenotype-altered T cells, wherein the phenotype-altered T cells are prepared by a method comprising culturing a population of T cells in vitro in the presence of a phenotype-altering composition comprising a phenotype-altering agent selected from the group consisting of a protein kinase A (PKA) inhibitor, an A2A adenosine receptor inhibitor, a GPR174 inhibitor, and combinations thereof for a time sufficient to alter a phenotype of at least a subpopulation of the population of T cells.
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Dependencies are inferred from the claim text.