Treatment of cancer harboring mutations in the tp53 gene and/or post-translational modifications in the p53 protein with parvoviruses
OwnerJosé María ALMENDRAL DEL RÍO, Carlos GALLEGO +1inventors
InventorsJosé María ALMENDRAL DEL RÍO, Carlos GALLEGO, Jon GIL-RANEDO
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Abstract
Treatment of cancer harboring mutations in the TP53 gene and/or post-translational modifications in the p53 protein. The present invention relates to the use of viruses belonging to the family Parvoviridae, genus Protoparvovirus, or combinations of such viruses with chemotherapy drugs, in the treatment of cancer. In particular the cancer is characterized by showing mutations in the TP53 gene and/or post-translational modifications in the p53 protein.
Claims19
A method for treatment of cancer, comprising administering a viral particle comprising a nucleotide sequence consisting essentially of:
- SEQ ID NO:
- 1 or SEQ ID NO:
- 2 to a subject in need thereof, wherein the cancer presents at least one mutation in the gene TP53 or p53 protein selected from the group consisting of:
- R273H, P72R, E258K, G245S, V173L and phosphorylation of the p53 protein.
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A pharmaceutical composition comprising a viral particle which in turn comprises a nucleotide sequence consisting essentially of:
- SEQ ID NO:
- 1 or SEQ ID NO:
- 2 in combination with a genotoxic chemotherapy drug.
Dependencies are inferred from the claim text.