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US 2023/0285464 A1Published application
Novel cellular receptors and uses thereof
AssigneeTrustees of Boston University
InventorsJohn T. NGO, Jeffrey Blye MCMAHAN
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Abstract
Described herein are polypeptides, systems, and methods that relate to using domains that bind specifically to a biotinylamide to control receptor and cellular activity.
Claims30
A synthetic signaling system comprising a cell, the cell comprising a small molecule-controlled signaling polypeptide comprising:
- a domain that binds specifically to a small molecule;
- a transmembrane domain;
- and
- an intracellular CAR stimulatory domain.
1 more element
A synthetic signaling system comprising:
- a cell, the cell comprising a small molecule-controlled signaling polypeptide comprising:
- a domain that binds specifically to a small molecule;
- a transmembrane domain;
- and
- an intracellular Notch receptor signaling domain;
- and
- an extracellular soluble molecule comprising:
- a small molecule;
- and
- an antibody or antibody reagent.
7 more elements
Dependencies are inferred from the claim text.