Compositions and methods of using a pla2-responsive drug delivery system
AssigneeThe Trustees of the University of Pennsylvania
InventorsZhiliang CHENG, Ling Q. QIN, Andrew B. TSOURKAS, Yulong WEI, Beth A. WINKELSTEIN, Sonia KARTHA
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions comprising a drug delivery system comprising a phospholipid that is hydrolyzed by phospholipase A2 (PLA2) enzyme and a drug. Also provided herein are methods for treating or for determining the location of a region to be treated or monitored in a subject in need thereof, the methods comprising: administering to the subject the disclosed composition.
Claims29
A composition comprising:
- a drug and a drug delivery system comprising a phospholipid that is hydrolyzed by phospholipase A2 (PLA2) enzyme.
(canceled)
-12. (canceled)
A method for treating a subject in need thereof, the method comprising:
- administering to the subject a drug delivery system comprising (i) a phospholipid that is hydrolyzed by phospholipase A2 (PLA2) enzyme and (ii) a drug.
(canceled)
(canceled)
-25. (canceled)
(canceled)
A method for determining the location of a region to be treated or monitored in a subject in need thereof, the method comprising:
- administering to the subject a composition comprising a phospholipid that is hydrolyzed by phospholipase A2 (PLA2) enzyme, optionally comprising a drug;
- and
- determining a location, within the subject, of any component of the composition,
- wherein the determining comprises magnetic resonance imaging, fluorescent imaging, computed tomography, nuclear imaging, or ultrasound.
-34. (canceled)
-41. (canceled)
-46. (canceled)
Dependencies are inferred from the claim text.