Engineered oxalate decarboxylases
AssigneesCodexis, Inc., Societe des Produits Nestle S.A.
InventorsChinping Chng, Nikki D. Kruse, Joyce Liu, Adam P. Silverman, Rebecca Hong Thibodeau, Tricia Windgassen
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Abstract
The present disclosure provides engineered oxalate decarboxylase (ODC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered oxalate decarboxylase polypeptides. The present disclosure also provides methods of using the engineered enzymes and compositions thereof for treating diseases or conditions associated with abnormal metabolism of oxalate.
Claims74
An engineered oxalate decarboxylase polypeptide comprising an amino acid sequence having at least 70%, 75%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or more sequence identity to a reference sequence corresponding to SEQ ID NO:
- 2, 4, 172, 320, 396, 616, 670, 750, or 906, or to a reference sequence corresponding to residues 1-359 of SEQ ID NO:
- 172, 320, or 396, wherein the amino acid sequence comprises one or more amino acid substitutions relative to the reference sequence corresponding to SEQ ID NO:
- 2, 4, 172, 320, 396, 616, 670, 750, or 906, or relative to the reference sequence corresponding to residues 1-359 of SEQ ID NO:
- 172, 320, or 396.
Dependencies are inferred from the claim text.