Devices and methods for reversible assembly of a flowcell
Assignee10x Genomics, Inc.
InventorsSiyuan XING, Pratomo Putra Alimsijah, Denis Pristinski, David Morgan, Rajiv Bharadwaj, Augusto Manuel Tentori, Francis Marcogliese, Yiran Zhang
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Abstract
Flowcell devices configured for reversible assembly, and methods of assembly, disassembly, and use thereof are provided. The methods and devices allow the interior of the flowcell device to be accessed without damaging, or otherwise disturbing sensitive samples and surfaces.
Claims31
A device comprising:
- a fluidic interface layer having a top surface, a bottom surface, and at least one side surface;
- a substrate layer having a top surface, a bottom surface, and at least one side surface;
- and
- a gasket disposed between the bottom surface of the fluidic interface layer and the top surface of the substrate layer, wherein a first portion of the gasket is wrapped over the at least one side surface of the fluidic interface layer and at least a portion of the top surface of the fluidic interface layer.
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A device comprising a gasket disposed between a fluidic interface layer and a substrate layer, and forming a fluid-tight seal therebetween, wherein the gasket comprises one or more voids defining a flow path with the substrate layer, wherein the contact between the gasket and the substrate layer is reversible, and wherein the device is configured to be sealed by applying negative pressure.
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A device comprising:
- a substrate layer;
- a fluidic interface layer;
- a gasket disposed therebetween;
- and
- a release fluid channel;
- wherein the gasket has a first void defining a flow path.
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Dependencies are inferred from the claim text.