Application of microbial glycosidase as an anti-viral therapeutic, prognostic, and diagnostic
AssigneeThe Regents of the University of California
InventorsCameron Martino, Benjamin Kellman, Nathan Lewis, Robin Knight, Jeffrey D. Esko, Daniel Sandoval, Thomas Mandel Clausen
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Abstract
Methods and compositions for diagnosing, preventing or treating a viral infection in a subject comprising administering to a subject in need thereof an effective amount of a glycosidase or a sulfatase to degrade a glycan, such as heparan sulfate, to inhibit viral infection, such as COVID-19. Methods for identifying a glycosidase, a sulfatase, or a microbe associated with increased susceptibility to viral infection in a subject.
Claims21
A method of preventing or treating a viral infection in a subject comprising administering to a human subject in need thereof an effective amount of a composition comprising a glycosidase or a sulfatase to degrade a glycan to inhibit viral infection.
A pharmaceutical composition comprising an effective amount of a glycosidase or a sulfatase to degrade heparan sulfate to inhibit viral infection and a pharmaceutically acceptable carrier.
A method of diagnosing or prognosing a viral infection in a subject comprising detecting a decrease in amounts of glycosidase, a sulfatase, B. ovatus or B. thetaiotaomicron in a biological sample from the subject, as compared to an earlier taken biological sample from the subject, or as compared to amounts of glycosidase, sulfatase, B. ovatus or B. thetaiotaomicron in a biological sample from a control subject.
A method of identifying a glycosidase, a sulfatase, or a microbe associated with increased susceptibility to viral infection in a subject, comprising determining a decrease in amounts of a glycosidase, sulfatase, B. ovatus or B. thetaiotaomicron in a biological sample from a subject infected with a virus, as compared to amounts of the glycosidase, sulfatase, B. ovatus or B. thetaiotaomicron in a biological sample from a control subject not having the viral infection.
Dependencies are inferred from the claim text.