Novel polyurethanes and their use in pharmaceutical dosage forms
AssigneeBASF SE
InventorsFerdinand Paul Brandl, Theo Smit, Karl Kolter, Felicitas Guth, Karl Haeberle, Frederic Lucas
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Abstract
The present invention relates to novel polyurethanes based on a diisocyanate, a carboxylic acid functionalized diol and an acid-free diol, their use as pharmaceutical excipients for improving gastrointestinal absorption, the respective pharmaceutical dosage forms and methods for making the polyurethanes.
Claims19
An isocyanate free polyurethane comprising components A to D with 45-70 wt% of at least one diisocyanate A with at least one ring in the molecular structure between the two isocyanate groups;
- with 15-40 wt% of at least one component B with i) two primary hydroxy groups, ii) one secondary or tertiary carboxylic acid group iii) a molecular weight between 100 and 250 g/mol and iv) no additional group reactive towards an isocyanate;
- with 5-30 wt% of at least one component C with i) at least two hydroxy groups, ii) a molecular weight between 60 and 250 g/mol, iii) no acid group and iv) no primary or secondary amine or thiol group and optionally with 0-5 wt% of one or more components D which i) contain one or two groups reactive toward isocyanate groups and ii) maximum one of these reactive groups is a hydroxy group, whereby a total amount of incorporated components A to D adds up to 100% by weight.
(canceled)
An isocyanate free polyurethane comprising components A to C with 50-65 wt% of isophorone diisocyanate as A;
- with 20-35 wt% of at least one component B selected from the group consisting of 2,2-bis(hydroxymethyl)butyric acid and 2,2-bis(hydroxymethyl)propionic acid, and with 5-30 wt% of at least one component C selected from the group consisting of 1,4-cyclohexane dimethanol, 1,3-cyclohexane dimethanol, 2,2-diethyl-1,3-propanediol, 2,5-dimethyl-2,5-hexanediol, isosorbide, and neopentyl glycol, whereby the total amount of incorporated components A to C adds up to 100% by weight.
Dependencies are inferred from the claim text.