# US 2023/0263168 A1 · Combined fungicidal preparations and methods for using thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2023/0263168 A1 - Document ID: US20230263168A1 - Status: Published application - Kind: A1 - Application number: 18/012,486 - Filed: 2021-06-23 - Published: 2023-08-24 - Earliest claimed: 2020-06-23 - Assignees: Save Foods Ltd. - Applicants: Save Foods Ltd. - Inventors: Neta MATIS; Dan SZTYBEL; Nimrod BEN YEHUDA - Web page: https://patentgrep.com/patent/US20230263168A1 ## CPC - A01N 59/26: Phosphorus; Compounds thereof - A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof - A01N 37/04: polybasic - A01N 37/16: containing the group [IMAGE cpc-sch-A01N-0934.gif]; Thio analogues thereof - A01N 37/36: containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids - A01N 43/50: 1,3-Diazoles; Hydrogenated 1,3-diazoles - A01N 59/00: Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds - A01P 3/00: Fungicides - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS ## Abstract The present invention is related to compositions, kits and articles such as for reducing pathogen load on a substrate. ## Claims ### Claim 1 A antimicrobial composition comprising an effective amount of an acid component, and a fungicidally effective amount of a fungicide; wherein said acid component comprises (i) an inorganic acid, a salt thereof or both; (ii) a C1-C10 carboxylic acid a salt thereof or both, or a combination of (i) and (ii); and wherein the effective amount of the acid component is so that the fungicidally effective amount of the fungicide is reduced by at least 10%, compared to a similar antimicrobial composition without the acid component. ### Claim 2 (depends on 1) The antimicrobial composition of claim 1, wherein the effective amount of the acid component comprises a weight per weight (w/w) ratio of said acid component to said fungicide within the antimicrobial composition of between 15:1 and 1:2. ### Claim 3 (depends on 1) The antimicrobial composition of claim 1, wherein the fungicidally effective amount is at least 30 ppm. ### Claim 4 (depends on 1) The antimicrobial composition of claim 1, wherein the effective amount of the acid component within said antimicrobial composition is at least 50 ppm; and wherein said C1-C10 carboxylic acid is selected from the group consisting of propionic acid, tartaric acid, glycolic acid, butanoic acid, pyruvic acid, citric acid, malic acid, mandelic acid, and lactic acid, including any salt and any combination thereof. ### Claim 5 (canceled) ### Claim 6 (depends on 1) The antimicrobial composition of claim 1, wherein said acid component comprises propionic acid and at least one additional C1-C10 carboxylic acid; and wherein said fungicide comprises an azole-based fungicide, a diazine-based fungicide or both. ### Claim 7 (depends on 1) The antimicrobial composition of claim 1, wherein said acid component comprises propionic acid, lactic acid and citric acid wherein a w/w ratio between (i) the propionic acid and (ii) any one of the lactic acid and the citric acid is between 2:1 and 1:2. ### Claim 8 (canceled) ### Claim 9 (depends on 1) The antimicrobial composition of claim 1, wherein said inorganic acid is selected from the group consisting of phosphorous acid, phosphoric acid, hydrochloric acid, sulfuric acid, nitric acid, including any salt and any combination thereof; optionally wherein said acid component comprises phosphorous acid. ### Claim 10 (canceled) ### Claim 11 (depends on 1) The antimicrobial composition of claim 1, wherein the composition further comprises an acceptable carrier, optionally wherein the acceptable carrier is a food-acceptable carrier. ### Claim 12 (canceled) ### Claim 13 (depends on 1) The antimicrobial composition of claim 1, further comprising an antimicrobial effective amount of an oxidizing agent wherein the antimicrobial effective amount of the oxidizing agent is at least 10 ppm and wherein a pH of said composition is between 0 and 7. ### Claim 14 (canceled) ### Claim 15 (canceled) ### Claim 16 (depends on 1) The antimicrobial composition of claim 1, wherein said composition further comprises an agent selected from the group consisting of: a carrier gas, a solvent, a surfactant, an additive, and a stabilizer or any combination thereof, and wherein a concentration of said agent within said composition is in a range from 0.01 to 20%; optionally wherein the agent comprises the surfactant at a concentration sufficient for stabilizing said antimicrobial composition. ### Claim 17 (canceled) ### Claim 18 (depends on 13) The antimicrobial composition of claim 13, wherein the oxidizing agent is selected from the group consisting of: a percarboxylic acid, hydrogen peroxide, urea hydrogen peroxide, sodium peroxide, calcium peroxide, silver or a silver salt, sodium percarbonate, sodium periodate, sodium persulfate, ammonium persulfate, perchloric acid, sodium perborate, silver (II) oxide, chlorine dioxide, benzoyl peroxide, a ketone peroxide, a peroxydicarbonate, a peroxyester, a dialkyl peroxide, a hydroperoxide, and a peroxyketal, including any salt and any combination thereof. ### Claim 19 (depends on 1) The antimicrobial composition of claim 1, wherein said antimicrobial composition is stable for at least 24h. ### Claim 20 A kit comprising a first compartment comprising (i) an inorganic acid, a salt thereof, or both; (ii) a C1-C10 carboxylic acid, a salt thereof, or both; or both (i) and (ii); and a second compartment comprising a fungicide wherein said inorganic acid is selected from the group consisting of phosphorous acid, phosphoric acid, hydrochloric acid, sulfuric acid, nitric acid, including any salt and any combination thereof. ### Claim 21 (canceled) ### Claim 22 (depends on 20) The kit of claim 20, wherein said C1-C10 carboxylic acid is selected from the group consisting of propionic acid, tartaric acid, glycolic acid, butanoic acid, pyruvic acid, citric acid, malic acid, mandelic acid, and lactic acid, including any salt and any combination thereof and wherein said fungicide comprises an azole-based fungicide, a diazine based fungicide or both; and wherein said kit further comprises an oxidizing agent. ### Claim 23 (canceled) ### Claim 24 (canceled) ### Claim 25 (depends on 20) The kit of claim 20, wherein the oxidizing agent is selected from the group consisting of: a percarboxylic acid, hydrogen peroxide, urea hydrogen peroxide, sodium peroxide, calcium peroxide, silver or a silver salt, sodium percarbonate, sodium periodate, sodium persulfate, ammonium persulfate, perchloric acid, sodium perborate, silver (II) oxide, chlorine dioxide, benzoyl peroxide, a ketone peroxide, a peroxydicarbonate, a peroxyester, a dialkyl peroxide, a hydroperoxide, and a peroxyketal, including any salt and any combination thereof; wherein any one of said first compartment, and said second compartment, further comprises an acceptable carrier; and optionally comprises an agent selected from the group consisting of: a surfactant, an additive, a solvent, and a stabilizer or any combination thereof; and wherein any one of said first compartment, said second compartment, and said third compartment is stable for at least 6 months; optionally wherein the acceptable carrier is a food-acceptable carrier, and wherein the kit further comprising instructions for dilution and optionally for mixing of said first compartment and said second compartment, so as to obtain a composition comprising a fungicidally effective amount of said fungicide. ### Claim 26 (canceled) ### Claim 27 (canceled) ### Claim 28 (canceled) ### Claim 29 (canceled) ### Claim 30 (depends on 1, 20) A method comprising contacting a substrate with an effective amount of (i) the antimicrobial composition of claim 1, or (ii) the kit of claim 20; thereby enhancing or prolonging activity of said fungicide, or controlling pathogen related decay of an edible matter; wherein said effective amount comprises a concentration of said fungicide within said composition or within said kit being between 50 and 10,000 ppm; optionally wherein said pathogen is a plant pathogen selected from the group consisting of a virus, a bacterium, a yeast and a fungus or any combination thereof. ### Claim 31 (canceled) ### Claim 32 (canceled) ### Claim 33 (canceled) ### Claim 34 (canceled) ### Claim 35 (canceled) ### Claim 36 (canceled) ### Claim 37 (canceled) ### Claim 38 (canceled) ### Claim 39 (depends on 1, 20) An article comprising a substrate in contact with the antimicrobial composition of claim 1, or with the kit of claim 20; wherein said substrate is selected for the group consisting of: an edible matter, a growth medium, a propagation medium, a harvesting surface, a container, a storage surface, a transport surface, a packaging surface, a treatment surface, and a processing surface or any combination thereof. ### Claim 40 (canceled) ### Claim 41 (depends on 39) The article of claim 39, wherein said substrate comprises the edible matter further comprising a hydrophobic coating, a fungicide residuals or both; wherein said hydrophobic coating comprises a water insoluble compound selected from the group comprising a lipid, a fatty acid, a water insoluble polysaccharide, and a water insoluble protein or any combination thereof; wherein said fungicide comprises an azole-based fungicide, a diazine-based fungicide or both; and wherein the edible matter is characterized by any of (i) reduced pathogen load, (ii) prolonged storage shelf-life or both (i) and (ii); compared to an edible matter treated with a composition or with a kit comprising a similar amount of the fungicide without the acid component. ### Claim 42 (canceled) ### Claim 43 (canceled) ### Claim 44 (canceled)