Method for detecting inflammasome proteins as biomarkers of neurological disorders
AssigneeUniversity of Miami
InventorsJuan Pablo DE RIVERO VACCARI, Robert W. KEANE, W. Dalton DIETRICH, Helen BRAMLETT
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods for detecting components of the inflammasome in a sample from a subject as markers for brain injuries such as multiple sclerosis, stroke or traumatic brain injury. Methods of using such inflammasome markers to determine prognosis, direct treatment and monitor response to treatment for the subject with a brain injury such as multiple sclerosis, stroke, mild cognitive impairment or traumatic brain injury are also described.
Claims21
1-49. (canceled)
A method of treating a patient with stroke, the method comprising:
- (a) measuring an expression level of at least one inflammasome protein in a biological sample obtained from a patient,
- (b) comparing the expression level of the at least one inflammasome protein in the biological sample obtained from the patient to a control;
- (c) diagnosing the patient with stroke when the expression level of the at least one inflammasome protein in the biological sample obtained from the patient is enhanced relative to the control;
- and
- (d) administering a standard of care treatment for stroke or stroke-related injury to the patient.
The method of 46, wherein the enhanced level of the at least one inflammasome protein is measured by an immunoassay utilizing one or more antibodies directed against the at least one inflammasome protein.
(canceled)
62-148. (canceled)
Dependencies are inferred from the claim text.