Method and intermediate compounds for the preparation of menaquinone mk-7
AssigneeVitasynth Sp. Z.O.O
InventorsAndrzej KRUKOWSKI, Konrad ZIELINSKI
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Abstract
The invention relates to a method and intermediate compounds for the preparation of menaquinone MK-7. The method for the preparation of menaquinone MK-7 is characterized in that, it comprises coupling of a compound of formula (11) with a compound of formula (17) in the presence of a base, to obtain a compound of formula (18), which is subjected to desulfonylation reaction in the presence of a palladium catalyst, to obtain a compound of formula (19), which is subjected to oxidation reaction, to obtain menaquinone MK-7. The invention also relates to compound (8), preferably in a crystalline form, which is a convenient intermediate compound for the preparation of menaquinone MK-7.
Claims15
A method for the preparation of a menaquinone of formula (20)
- characterized in that, the method comprises coupling a compound of formula (11)
- with a compound of formula (17)
- in the presence of a base, to obtain a compound of formula (18)
- which is subjected to desulfonylation reaction in the presence of a palladium catalyst, to obtain a compound of formula (19)
- which is subjected to oxidation reaction, to obtain the menaquinone of formula (20), wherein R1 and R2 are independently —C1-6-alkyl, —(CH2)n-O—C1-6-alkyl or benzyl, and wherein n is 1 or 2, wherein X is Br, Cl, or I, wherein both R3 and R4 are hydrogen, or one from R3 and R4 is hydrogen and the second is phenylsulfonyl group.
A compound of formula (8)
A compound of formula (11)
- wherein R1 and R2 are independently —C1-6-alkyl, —(CH2)n-O—C1-6-alkyl or benzyl, and
- wherein n is 1 or 2.
A compound of formula (19)
- wherein R1 and R2 are independently —C1-6-alkyl, —(CH2)n-O—C1-6-alkyl or benzyl,
- wherein n is 1 or 2.
- wherein for R1 being —C1-6-alkyl, —(CH2)n-O—C1-6-alkyl or benzyl, R2 is —(CH2)n-O—C1-6-alkyl,
- wherein for R2 being —C1-6-alkyl, —(CH2)n-O—C1-6-alkyl or benzyl, R1 is —(CH2)n-O—C1-6-alkyl.
Dependencies are inferred from the claim text.