Compositions and methods for treating hair follicle-linked conditions
OwnerJeppe Christian Mouritsen, Rikke Nørregaard-Sarup +1inventors
InventorsJeppe Christian Mouritsen, Rikke Nørregaard-Sarup, Peter Rahbek Østergaard
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Abstract
Disclosed are compositions comprising one or more enzymes capable of catalysing the hydrolysis of keratinocyte effector molecules such as protein keratins that support the function and integrity of the human skin and its appendages such as the hair follicle that are supported by keratinocytes to maintain the biological barrier, function and struture. The compositions are useful in treating follicular dermatoses and hair follicle-linked conditions, such as Hirsutism and Hidradenitis suppurativa. The compositions may also be used to loosen hair from the skin and thereby be used for removing undesired hair from the human body.
Claims21
A composition comprising one or more enzymes capable of catalysing the hydrolysis of keratinocyte effector molecules such as protein keratins that support the function and integrity of the human skin and its appendages such as the hair follicle that are supported by keratinocytes to maintain the biological barrier, its function and struture, where the composition is:
- a. a pharmaceutical composition, comprising at least one pharmaceutically acceptable ingredient in addition to the one or more enzymes;
- or
- b. a cosmetic composition, comprising at least one cosmetically acceptable ingredient in addition to the one or more enzymes
The composition according to any of the preceding claims, wherein the composition promotes delivery of enzyme to the site of action to facilitate its function and purpose formulated as a gel, cream such as semisolid emulsions of a hydrophilic and a hydrophobic phase, semisolid and/or liquid including nano- and microemulsions and more than two phases, cloth, sponge, paste, pellet, shampoo, soap, jelly, lotion, foam, ointment, film, spray, solution, liquid, oil, ointment, suspension of subnano- to micrometer sized particles in a liquid or solid suspension, medical patch, medical patch with microneedles, medical patch with dissolving microneedles, derma roller with microneedles, iontophoresis, compressed air pressure, solid skin implant, semi-solid skin implant, liquid skin implant, skin tattoo, roll-on, swab, syrup, tape, wafer or injectable liquid, injectable solution, injectable emulsion, or injectable suspension.
Dependencies are inferred from the claim text.