Automated diazomethane generator, reactor and solid phase quencher

A process for producing and quenching diazomethane of Formula 1 (CH2N2), with an automated apparatus, the process comprising:

• i. continuously flowing a stock solution of N-methyl-N-nitroso amine of formula 2,
• Formula 2, wherein R is an electron-withdrawing radical;
• in an organic solvent and mixing with an aqueous inorganic base at a T-mixer to form a mixture and further passing the mixture through a capillary micro reactor at a temperature in a range of 20 to 30° C. to form diazomethane,
• ii. separating an aqueous layer and an organic layer, wherein the organic layer comprises 0.1-0.4 M diazomethane, with a continuous flow micro-separator;
• iii. reacting the organic layer with a carboxylic acid, phenol, an alkyne, an anhydride, a carboxyl metal organic framework (MOF), or MOF coated cotton to form a corresponding ester, a pyrazole, an ether, a diazo ketone, a stable carboxyl MOF or a stable MOF coated cotton fiber.