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US 2023/0233597 A1Published application
Diagnostic drug, diagnostic method and diagnostic device for permeability of intestinal mucosa
AssigneesNational University Corporation Shimane University, Koyo Chemical Co., Ltd.
InventorsKoichiro WADA, Haruki USUDA, Morihiko NAKAMURA, Yoshimori TAKAMORI, Seiji KUROZUMI
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Abstract
Provided is a diagnostic drug for evaluating permeability of intestinal mucosa, including chitin and/or chitosan as a main component. The chitin and/or chitosan to be used preferably has a weight average molecular weight prepared to a range of from 1,000 to 11,600.
Claims10
1-4. (canceled)
A diagnostic method, comprising:
- orally administering or enema administering chitin and/or chitosan to an animal, the animal being other than a human;
- and
- measuring a concentration of the administered substance in blood after a lapse of a predetermined period of time,
- to thereby evaluate permeability of intestinal mucosa of the animal.
1 more element
A diagnostic method, comprising:
- orally administering or enema administering chitin and/or chitosan to a test subject;
- and
- measuring a concentration of the administered substance in blood after a lapse of a predetermined period of time,
- to thereby evaluate permeability of intestinal mucosa of the test subject.
1 more element
(canceled)
A food and drink evaluation method, comprising:
- allowing a test subject to eat and drink a single or a plurality of specific foods and drinks;
- allowing the test subject to orally ingest chitin and/or chitosan during the eating and drinking, or before or after the eating and drinking;
- and
- measuring a concentration of the ingested substance in blood after a lapse of a predetermined period of time from the oral ingestion,
- to thereby determine whether the foods and drinks have a potential to serve as a factor affecting permeability of intestinal mucosa of the test subject.
2 more elements
(canceled)
An evaluation method, comprising:
- administering a given substance;
- separately orally administering or enema administering chitin and/or chitosan;
- and
- measuring blood concentrations of the orally administered substance or the enema administered substance before and after the administration of the given substance,
- to thereby evaluate whether the given substance has a normalizing action on permeability of intestinal mucosa, and how strong the normalizing action, when present, is.
2 more elements
13-14. (canceled)
Dependencies are inferred from the claim text.