Gastroretentive structured dosage form
AssigneeAron H. Blaesi
InventorsAron H. Blaesi, Nannaji Saka
Life of this patent
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Abstract
Many drug therapies could be greatly improved by dosage forms that reside in the stomach for prolonged time and release the drug slowly. In this specification, therefore, a gastroretentive structured dosage form is disclosed. The dosage form comprises a solid core having at least a fluid-absorptive first excipient. The dosage form further comprises a semi-permeable surface layer substantially encapsulating said solid core. The surface layer comprises at least a mechanically strengthening second excipient. Upon ingestion, the surface layer-supported solid core expands with physiological fluid absorption and remains in the stomach for prolonged time.
Claims28
A pharmaceutical dosage form comprising:
- a drug-containing solid having a fluid-absorptive solid core and a mechanically strengthening, semi-permeable surface layer;
- said fluid-absorptive solid core comprising at least a fluid-absorptive first excipient;
- said fluid-absorptive solid core further substantially encapsulated by said mechanically strengthening, semi-permeable surface layer, said semi-permeable surface layer comprising at least a mechanically strengthening second excipient;
- whereby
- upon exposure of the dosage form to a physiological fluid, the surface layer-encapsulated solid core expands primarily with fluid absorption, thereby transitioning to a viscous or semi-solid mass;
- and
- the mechanically strengthening, semi-permeable surface layer forms a semi-permeable, viscoelastic membrane;
- and
- the drug-containing solid forms an expanded, viscoelastic composite mass.
A pharmaceutical dosage form comprising:
- a drug-containing solid having a fluid-absorptive solid core and a semi-permeable surface layer;
- said fluid-absorptive solid core comprising a three-dimensional structural framework of one or more structural elements;
- said elements comprising at least a first excipient, wherein said first excipient includes at least a fluid-absorptive polymeric constituent;
- said semi-permeable surface layer substantially encapsulating said elements;
- said semi-permeable surface layer further comprising at least a second excipient, said second excipient including at least a mechanically strengthening polymeric constituent;
- whereby
- upon exposure of the dosage form to physiological fluid, the surface layer-supported solid core expands with fluid absorption, thereby forming a viscoelastic composite mass.
A pharmaceutical dosage form comprising:
- a drug-containing solid having a fluid-absorptive solid core and a semi-permeable surface layer;
- said fluid-absorptive solid core comprising a three-dimensional structural network of criss-crossed stacked layers of fibers;
- said fibers comprising at least a first excipient, wherein said first excipient includes at least a fluid-absorptive polymeric constituent;
- said semi-permeable surface layer substantially encapsulating said fibers;
- said semi-permeable surface layer further comprising at least a second excipient, said second excipient including at least a mechanically strengthening polymeric constituent;
- whereby
- upon exposure of the dosage form to physiological fluid, the surface layer-supported solid core expands with fluid absorption, thereby forming a viscoelastic composite mass.
Dependencies are inferred from the claim text.