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AssigneeIndena S.p.A.
InventorsFabio Donzelli, Pietro Allegrini, Alessandro Andreani, Andrea Gambini, Davide Berlanda
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The invention relates to a process for the preparation of colchicine 1 from colchicoside 2 which comprises enzymatic conversion of colchicoside 2 to 3-O-demethylcolchicine 3, wherein the enzyme used is a cellulase. According to another aspect of the invention, 3-O-demethylcolchicine 3 can be converted to colchicine 1 using an alkylating agent. The invention also relates to a process or enriching the colchicine 1 content of extracts from plants belonging to the Colchicaceae family containing colchicine 1, colchicoside 2 and 3-(9-demethyl colchicine 3, which comprises conversion by means of a colchicoside 2 cellulase to 3-O-demethylcolchicine 3, followed by conversion of 3-O-demethylcolchicine 3 to colchicine 1 using an alkylating agent.
A process for the preparation of colchicine 1 from colchicoside 2 comprising
Process for enriching the colchicine 1 content of extracts of plants belonging to the Colchicaceae family containing colchicine 1, colchicoside 2 and 3-O-demethylcolchicine 3, said process comprising:
Process for the synthesis of colchicine comprising converting 3-O-demethylcolchicine 3 to colchicine 1 by alkylation with a methylsulphonate as alkylating agent.
Dependencies are inferred from the claim text.