Compounds for sensing reactive oxygen species and methods for using the same
AssigneeWake Forest University Health Sciences
InventorsJohn C. Lukesh, III, Katherine Virginia Ambrose
Life of this patent
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Abstract
Provided herein according to some embodiments of the invention are aryl boronate and/or aryl diaminoboryl compounds. Also provided are methods of detecting the presence of hydrogen peroxide (H2O2) and/or other reactive oxygen species (ROS) in a cell and/or tissue by contacting the cell and/or tissue with aryl boronate and/or aryl diaminoboryl compounds. Also provided according to embodiments of the invention are methods of producing persulfides in the presence of hydrogen peroxide (H2O2) and/or other reactive oxygen species (ROS) in a cell and/or tissue by contacting the cell and/or tissue with aryl boronate and/or aryl diaminoboryl compounds.
Claims21
A compound of Formula I:
- wherein:
- R1 is H, halo, alkyl, heteroalkyl, aryl, or heteroaryl, wherein the alkyl, heteroalkyl, aryl, or heteroaryl is optionally substituted, and/or R1 comprises at least one of a prodrug moiety and a reporter moiety;
- each Y is independently NRa or O;
- W is NRb, S, or O;
- Ra and Rb are each independently H or alkyl, optionally substituted;
- and
- R′ and R″ are each independently H or alkyl, optionally substituted, or R′ and R″ together with the Y atoms to which they are attached form a cyclic structure containing up to 5 carbon atoms, optionally substituted by one or more alkyl, heteroalkyl, aryl, heteroaryl, halogen, —OH, alkoxy, carbonyl and/or carboxy groups;
- or a pharmaceutically acceptable salt thereof.
A compound of Formula II:
- wherein:
- R2 is H, alkyl, heteroalkyl, aryl, or heteroaryl, wherein the alkyl, heteroalkyl, aryl, or heteroaryl is optionally substituted, and/or wherein R2 comprises at least one of a reporter moiety and a prodrug moiety,
- each Y is independently NRc or O;
- Rc is H or alkyl, optionally substituted;
- and
- R′ and R″ are each independently H or alkyl, optionally substituted, or R′ and R″ together with the Y atoms to which they are attached form a cyclic structure containing up to 5 carbon atoms, optionally substituted by one or more alkyl, heteroalkyl, aryl, heteroaryl, halogen, —OH, alkoxy, carbonyl and/or carboxy groups;
- and
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.