A application of cyathane diterpenoids in preparation of drugs for treating neuroinflammation
AssigneeNorthwest A&F University
InventorsJinMing Gao, Chenyu Cao
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Abstract
The present invention discloses the application of cyathane diterpenoids in preparation of drugs for treating neuroinflammation. Seven cyathane diterpenoids 1-7 can significantly prevent LPS-induced BV-2 microglia from producing NO. The most active compound as 6 can reverse M1/M2 polarization of the microglia. 6 inhibits the pro-inflammatory proteins including iNOS and COX-2 through MAPK/NF-κB signaling pathways and promote the anti-inflammatory factors including IL-10 and ARG-1. An application prospect of the anti-inflammatory cyathane diterpenoids in the treatment of the neurodegenerative diseases is achieved.
Claims2
The cyathane diterpenoid sarcodonin A numbered as 1 is isolated from fruiting bodies of Sarcodon scabrosus (Fr.) Karst and the derivatives of sarcodonin A numbered as 2-7 are synthesized;
Dependencies are inferred from the claim text.