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US 2023/0226157 A1Published application
Anti-tumor fusion protein, preparation method therefor and application thereof
AssigneeGuangdong Taihe Medicine Science & Technology Co., Ltd
InventorsYingqi ZHANG, Fulin FAN
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Abstract
Provided are an anti-tumor fusion protein, a preparation method therefor and an application thereof. Specifically, the fusion protein contacts a CPP element, an optional linking element, and a SH2 domain of SHP2 or SHP1 or an active fragment thereof. The obtained fusion protein has an extremely excellent anti-tumor effect.
Claims11
A fusion protein, wherein the fusion protein has the structure as shown in Formula I or II from the N-terminus to the C-terminus:
- Z1-L-Z2 (I)
- Z2-L-Z1 (II)
- wherein
- Z1 is a CPP element;
- L is no or a connecting element;
- Z2 is a SH2 domain of SHP2 and/or SHP1 or an active fragment thereof;
- “-” denotes a peptide bond or peptide linker connecting the above elements.
4 more elements
Dependencies are inferred from the claim text.