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US 2023/0225975 A1Published application
Dexamethasone prodrug compositions and uses thereof
AssigneeRipple Therapeutics Corporation
InventorsIan Charles PARRAG, Matthew Alexander John STATHAM, Kyle BATTISTON, Dimitra LOUKA, Hans Christian FISCHER, J. Paul SANTERRE, Wendy Alison NAIMARK
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Abstract
The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.
Claims1
A compound described by the formula (A-IV):
- or a pharmaceutically acceptable salt thereof, wherein
- L is —C(O)O—(RA)—OC(O)—;
- RA is selected from C1-20 alkylene, a linear or branched heteroalkylene of 1 to 20 atoms, a linear or branched C2-20 alkenylene, a linear or branched C2-20 alkynylene, a C5-10 arylene, a cyclic system of 3 to 10 atoms, or O—(RA)—O is a radical of a polyol and comprises at least one free hydroxyl group or O—(RA)—O is selected from:
- —O(CH2CH2O)nCH2CH2O—,
- —O(CH2CH2CH2CH2O)mCH2CH2CH2CH2O—, or
- —O(CH2CH(CH3)O)pCH2CH(CH3)O—;
- and
- n, m, and p are integers from 1 to 10.
5 more elements
Dependencies are inferred from the claim text.