Compositions comprising aromatic dipeptides-based structures encapsulating an esterase and uses thereof
AssigneesMigal Galilee Research Institute Ltd., Ramot at Tel-Aviv University Ltd.
InventorsLihi ADLER-ABRAMOVICH, Livnat AFRIAT-JURNOU
Life of this patent
Estimating the term…
Abstract
A composition including nano- or microspheres, and/or tubular nanostructures, each made of a plurality of aromatic dipeptides including end-capping modified aromatic dipeptides, non-modified aromatic dipeptides, or a combination thereof; and encapsulating an esterase or a functional fragment thereof; as well as methods of use. The plurality of aromatic dipeptides may include the end-capping modified aromatic dipeptides only.
Claims40
A composition comprising a plurality of nano- or microspheres, and/or a plurality of tubular nanostructures, each encapsulating an esterase or a functional fragment thereof, wherein each one of said nano- and/or microspheres, or said tubular nanostructures, being formed of a plurality of aromatic dipeptides comprising end-capping modified aromatic dipeptides, non-modified aromatic dipeptides, or a combination thereof;
- and
- said composition having a pH suitable for the activity of said esterase.
3-4. (canceled)
The composition of claim 42, wherein:
- (i) said plurality of aromatic dipeptides comprises a combination of said end-capping modified aromatic dipeptides and said non-modified aromatic dipeptides, and the molar ratio between said end-capping modified aromatic dipeptides and said non-modified aromatic dipeptides in said combination ranges from about 1:1 to about 1:100 respectively;
- (ii) each one of said end-capping modified aromatic dipeptides is protected at the N-terminus thereof;
- or
- (iii) each one of said non-modified aromatic dipeptides is phenylalanine-phenylalanine dipeptide;
- and/or each one of said end-capping modified aromatic dipeptides is an N-terminus modified phenylalanine-phenylalanine dipeptide.
6-7. (canceled)
9-11. (canceled)
(canceled)
23-25. (canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.