D-xylulose 4-epimerase, mutants and uses thereof

A polypeptide has D-xylulose 4-epimerase activity, wherein the polypeptide is selected from any one of the groups consisting of (a) to (d):

• (a) a polypeptide encoded by a sequence having at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, at least 96%, at least 95%, at least 97%, at least 98%, or at least 99% sequence identity to the sequence as set forth in any one of SEQ ID NOs:
• 2-32;
• (b) a polypeptide encoded by a polynucleotide that hybridizes, under a very high stringency condition, to a polynucleotide of (i) or (ii):
• (i) a polynucleotide encoding an amino acid sequence as set forth in any one of SEQ ID NOs:
• 2-32;
• (ii) a full-length complementary polynucleotide of (i);
• (c) a polypeptide that is a mutant of the polypeptide as set forth in any one of SEQ ID NOs:
• 2-32, the mutant comprising a substitution, repetition, deletion or addition of one or more amino acids at one or more positions, and the polypeptide still having D-xylulose 4-epimerase activity;
• and
• (d) fragments of the polypeptides shown by (a), (b), (c), which have D-xylulose 4-epimerase activity;
• or
• wherein the polypeptide comprises or consists of amino acid sequences having at least 96% sequence identity to the sequence as set forth in any one of SEQ ID NOs:
• 33-122;
• optionally, the polypeptide comprises or consist of amino acid sequences having at least 98.3%, at least 98.5%, at least 98.7%, at least 98.9%, at least 99.1%, at least 99.3%, at least 99.5%, at least 99.7%, or 100% sequence identity to any one of the polypeptides encoded by SEQ ID NOs:
• 33-122.